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Biology of the schistosome lung-stage schistosomulum.

机译:血吸虫性肺阶段血吸虫病的生物学。

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摘要

Past and more recent research has examined the ultrastructure, metabolism, cell biology, genomics and post-genomics of schistosome schistosomula. These areas are considered and discussed in this review with particular emphasis on (1) the early migration phases through the host, (2) interaction of the host immune response with the parasite surface, (3) glucose uptake mechanisms, and (4) defining the transcriptional profiles of lung-stage schistosomula compared with other developmental stages using microarrays. The microarray profiling studies suggest caution is required when considering the use of schistosomes obtained by in vitro means for molecular or biochemical studies.
机译:过去和最近的研究已经检查了血吸虫血吸虫的超微结构,代谢,细胞生物学,基因组学和后基因组学。在本综述中考虑并讨论了这些领域,并特别着重于(1)通过宿主的早期迁移阶段;(2)宿主免疫应答与寄生虫表面的相互作用;(3)葡萄糖摄取机制;以及(4)确定与使用微阵列芯片的其他发育阶段相比,肺阶段血吸虫的转录谱。微阵列分析研究表明,在考虑使用通过体外手段获得的血吸虫进行分子或生化研究时需要谨慎。

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