• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Parasitology >The host-parasite relationship in pregnant cattle infected with Neospora caninum.
【24h】

The host-parasite relationship in pregnant cattle infected with Neospora caninum.

机译：犬新孢子虫感染的怀孕牛的寄主-寄生虫关系。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The protozoan parasite Neospora caninum is an important cause of reproductive disease in cattle worldwide. The dog is a definitive host for the parasite and the oocyst stage, shed in the faeces, is a source of infection for cattle through consumption of contaminated feed or water. In addition, transplacental transmission of N. caninum is a very efficient means of the parasite infecting a new host and this can occur in successive pregnancies and over several generations. Neospora parasites may cause disease during pregnancy resulting in death of the foetus or birth of live congenitally infected calves that may show some neurological clinical signs at birth. The stage of pregnancy at which infection/parasitaemia occurs is an important factor in determining disease severity. Neospora infection in the first trimester of pregnancy may have more severe consequences for the foetus compared with infection occurring in the final trimester. The host-parasite relationship during pregnancy is a fascinating interaction and research in this area will improve understanding of disease pathogenesis and the various consequences of the host immune response, being host-protective, parasite protective and contributing to disease pathology. Pregnancy poses an interesting problem for the immune system of the dam as she is essentially carrying a semi-allogeneic tissue graft (the foetus) without immunological rejection taking place. To facilitate the pregnancy the cytokine environment in the placenta favours the regulatory Th-2-type cytokines, whose role is to counteract the pro-inflammatory Th1-type immune responses. Protective immunity to N. caninum, similar to many other intracellular parasites, involves Th1-type immune responses, which may pose problems for the dam trying to control a Neospora infection during pregnancy.This paper will discuss the host-parasite relationship at different stages of gestation in pregnant cattle and review the implications of this research for our understanding of disease pathogenesis, parasite transmission and host protection.
机译：原生动物寄生新孢子虫（Neospora caninum）是全世界牛生殖疾病的重要原因。狗是寄生虫的最终宿主，卵囊阶段排泄在粪便中，是通过食用受污染的饲料或水而感染牛的来源。另外，犬新孢子虫的胎盘传播是寄生虫感染新宿主的非常有效的手段，并且这可以在连续的妊娠中以及数代之后发生。新孢子虫寄生虫可能在怀孕期间引起疾病，导致胎儿死亡或活的先天性感染小牛的出生，这些小牛在出生时可能会显示出一些神经系统的临床症状。发生感染/寄生虫血症的怀孕阶段是确定疾病严重程度的重要因素。与孕晚期的感染相比，孕早期的新孢子虫感染对胎儿的后果可能更严重。孕期宿主与寄生虫之间的关系是一种令人着迷的相互作用，该领域的研究将增进人们对疾病发病机理和宿主免疫反应的各种后果的了解，具有宿主保护，寄生虫保护作用并有助于疾病病理。怀孕对大坝的免疫系统构成了一个有趣的问题，因为她基本上是在携带半异基因的组织移植物（胎儿）而没有发生免疫排斥反应。为了促进妊娠，胎盘中的细胞因子环境有利于调节Th-2型细胞因子，其作用是抵消促炎性Th1型免疫反应。与犬许多其他细胞内寄生虫相似，对犬新孢子虫的保护性免疫也涉及Th1型免疫反应，这可能为大坝试图控制妊娠期新孢子虫感染带来麻烦。本文将讨论不同阶段的宿主与寄生虫之间的关系。妊娠牛的妊娠，并回顾本研究对我们对疾病发病机理，寄生虫传播和宿主保护的理解的意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号