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首页> 外文期刊>Parasitology >Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil against Dactylogyrus intermedius.
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Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil against Dactylogyrus intermedius.

机译：肉桂皮精油中肉桂醛和肉桂酸的驱虫效果

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Utilization of chemical pesticide to control monogenean diseases is often restricted in many countries due to the development of pesticide resistance and concerns of chemical residues and environmental contamination. Thus, the use of antiparasitic agents from plants has been explored as a possible way for controlling monogenean infections. Extracts from Cinnamomum cassia were investigated under in vivo conditions against Dactylogyrus intermedius in goldfish. The two bioactive compounds, cinnamaldehyde and cinnamic acid, were identified using nuclear magnetic resonance and electrospray ionization mass spectrometry. The 48 h median effective concentrations (EC50) for these compounds against D. intermedius were 0·57 and 6·32 mg L-1, respectively. The LD50 of cinnamaldehyde and cinnamic acid were 13·34 and 59·66 mg L-1 to goldfish in 48 h acute toxicity tests, respectively. These data confirm that cinnamaldehyde is effective against D. intermedius, and the cinnamaldehyde exhibits potential for the development of a candidate antiparasitic agent.
机译：由于抗药性的发展以及对化学残留物和环境污染的关注，在许多国家中常常限制使用化学农药来控制单基因疾病。因此，已经探索使用来自植物的抗寄生虫剂作为控制单基因感染的可能方法。在体内条件下研究了肉桂中肉桂的提取物对金鱼中间inter的作用。使用核磁共振和电喷雾电离质谱法鉴定了两种生物活性化合物，肉桂醛和肉桂酸。这些化合物对抗中间D病的48小时中位有效浓度（EC50）分别为0·57和6·32 mg L-1。在48小时的急性毒性试验中，肉桂醛和肉桂酸的LD50对金鱼的LD50分别为13·34和59·66 mg L-1。这些数据证实了肉桂醛对中间D虫有效，并且肉桂醛具有开发候选抗寄生虫剂的潜力。

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