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Implications of co-infection of Leptomonas in visceral leishmaniasis in India.

机译：在印度内脏租赁中，Leptomon的共同感染的影响。

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摘要

Protozoan parasites Leishmania donovani (family: Trypanosomatidae) cause fatal visceral leishmaniasis (VL) and the infection relapses in apparently cured population as post kala-azar dermal leishmaniasis (PKDL) in the Indian subcontinent. In recent years co-infection of another Trypanosomatid parasite Leptomonas with L. donovani during VL/PKDL in this region has become prominent. The observation of clinically lesser-known insect parasite, Leptomonas in leishmaniasis is intriguing to researchers. The presence of Leishmania look alike Leptomonas in the cultures of clinical isolates of Leishmania has been worrisome to those, who prefer to work with pure Leishmania cultures for drug and vaccine development or immune response studies. The exact implications of such a co-habitation, which might lead to a delay in the diagnostics of VL and elevate mortality, need a thorough investigation. Also whether Leptomonas is involved in leishmaniasis manifestation needs to be ascertained. Thus we are currently witnessing a new paradigm of a parasitic co-infection in VL/PKDL cases in India and this review outlines various opportunities for further research in understanding such emerging co-infection.
机译：原生动物寄生虫多形性利什曼原虫（Trypanosomatidae）引起致命的内脏利什曼病（VL），在印度次大陆，由于黑热病后皮肤利什曼病（PKDL），治愈的人群中感染复发。近年来，在该区域的VL / PKDL期间，另一种锥虫寄生虫Leptomonas与donovani乳杆菌的共感染变得很突出。研究人员对临床上鲜为人知的昆虫寄生虫Leptomonas在利什曼病中的观察很感兴趣。利什曼原虫临床分离株培养物中的利什曼原虫的外观类似于细单胞菌，这对于那些喜欢与纯利什曼原虫培养物一起用于药物和疫苗开发或免疫应答研究的人们来说是令人担忧的。这种同居的确切含义可能会导致VL的诊断延迟和死亡率上升，需要进行彻底的研究。此外，还需要确定Leptomonas是否参与了利什曼病的表现。因此，我们目前在印度目睹了VL / PKDL病例中的寄生虫共感染的新范例，该综述概述了进一步研究以了解这种新兴共感染的各种机会。

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