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首页> 外文期刊>Parasitology >Impact of chemical structure of flavanol monomers and condensed tannins on in vitro anthelmintic activity against bovine nematodes
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Impact of chemical structure of flavanol monomers and condensed tannins on in vitro anthelmintic activity against bovine nematodes

机译：黄烷醇单体和缩合单宁的化学结构对体外对牛线虫驱虫活性的影响

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摘要

Plants containing condensed tannins (CT) may have potential to control gastrointestinal nematodes (GIN) of cattle. The aim was to investigate the anthelmintic activities of four flavan-3-ols, two galloyl derivatives and 14 purified CT fractions, and to define which structural features of CT determine the anti-parasitic effects against the main cattle nematodes. We used in vitro tests targeting L1 larvae (feeding inhibition assay) and adults (motility assay) of Ostertagia ostertagi and Cooperia oncophora. In the larval feeding inhibition assay, O. ostertagi L1 were significantly more susceptible to all CT fractions than C. oncophora L1. The mean degree of polymerization of CT (i.e. average size) was the most important structural parameter: large CT reduced larval feeding more than small CT. The flavan-3-ols of prodelphinidin (PD)-type tannins had a stronger negative influence on parasite activity than the stereochemistry, i.e. cis-vs trans-configurations, or the presence of a gallate group. In contrast, for C. oncophora high reductions in the motility of larvae and adult worms were strongly related with a higher percentage of PDs within the CT fractions while there was no effect of size. Overall, the size and the percentage of PDs within CT seemed to be the most important parameters that influence antiparasitic activity.
机译：含有缩合单宁（CT）的植物可能具有控制牛胃肠道线虫（GIN）的潜力。目的是研究四种黄烷-3-醇，两种没食子酰基衍生物和14种纯化的CT馏分的驱虫活性，并确定CT的哪些结构特征决定了对主要牛线虫的抗寄生虫作用。我们使用了针对L1幼虫（进食抑制试验）和成年雌性Ostertagia ostertagi和Cooperia oncophora的体外试验。在幼虫摄食抑制试验中，O。ostertagi L1对所有CT组分的敏感度均比C. oncophora L1高。 CT的平均聚合度（即平均大小）是最重要的结构参数：较大的CT可以减少幼虫的进食，而不是较小的CT。与立体化学（即顺式-反式-顺式构型或没食子酸酯基团的存在）相比，原飞鸟草素（PD）型单宁的黄烷-3-醇对寄生虫活性具有更强的负面影响。相比之下，对于C. oncophora，幼虫和成虫蠕动的高度降低与CT分数中PD的百分比较高密切相关，而大小没有影响。总体而言，CT中PD的大小和百分比似乎是影响抗寄生虫活性的最重要参数。

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