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首页> 外文期刊>Parasitology >Of mice and men: asymmetric interactions between Bordetella pathogen species.
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Of mice and men: asymmetric interactions between Bordetella pathogen species.

机译：小鼠和男性：博德特氏菌病原体之间的不对称相互作用。

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摘要

In a recent experiment, we found that mice previously infected with Bordetella pertussis were not protected against a later infection with Bordetella parapertussis, while primary infection with B. parapertussis conferred cross-protection. This challenges the common assumption made in most mathematical models for pathogenic strain dynamics that cross-immunity between strains is symmetric. Here we investigate the potential consequences of this pattern on the circulation of the two pathogens in human populations. To match the empirical dominance of B. pertussis, we made the additional assumption that B. parapertussis pays a cost in terms of reduced fitness. We begin by exploring the range of parameter values that allow the coexistence of the two pathogens, with or without vaccination. We then track the dynamics of the system following the introduction of anti-pertussis vaccination. Our results suggest that (1) in order for B. pertussis to be more prevalent than B. parapertussis, the former must have a strong competitive advantage, possibly in the form of higher infectivity, and (2) because of asymmetric cross-immunity, the introduction of anti-pertussis vaccination should have little effect on the absolute prevalence of B. parapertussis. We discuss the evidence supporting these predictions, and the potential relevance of this model for other pathogens.
机译：在最近的实验中，我们发现先前感染过百日咳博德特氏菌的小鼠没有受到保护，不能再感染副百日咳博德特氏菌，而原发性百日咳博德特氏菌则赋予了交叉保护作用。这挑战了大多数数学模型中针对病原体动力学的共同假设，即菌株之间的交叉免疫是对称的。在这里，我们调查了这种模式对人类中两种病原体循环的潜在影响。为了匹配百日咳博德特氏菌在经验上的优势，我们做出了另一个假设，即副百日咳博德特氏菌在降低适应性方面付出了代价。我们首先探讨允许或不伴有疫苗接种的两种病原体共存的参数值范围。然后，我们在引入抗百日咳疫苗后跟踪系统的动态。我们的研究结果表明，（1）为了使百日咳博德特氏菌比副百日咳博德特氏菌更流行，前者必须具有强大的竞争优势，可能具有较高的传染性，以及（2）由于不对称的交叉免疫，引入百日咳疫苗对百日咳博德特氏菌的绝对流行率影响不大。我们讨论了支持这些预测的证据，以及该模型与其他病原体的潜在相关性。

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