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首页> 外文期刊>Parasitology >Transgenesis of schistosomes: approaches employing mobile genetic elements.
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Transgenesis of schistosomes: approaches employing mobile genetic elements.

机译：血吸虫的转基因：采用移动遗传元件的方法。

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Draft genome sequences for Schistosoma mansoni and Schistosoma japonicum are now available. However, the identity and importance of most schistosome genes have yet to be determined. Recently, progress has been made towards the genetic manipulation and transgenesis of schistosomes. Both loss-of-function and gain-of-function approaches appear to be feasible in schistosomes based on findings described in the past 5 years. This review focuses on reports of schistosome transgenesis, specifically those dealing with the transformation of schistosomes with exogenous mobile genetic elements and/or their endogenous relatives for the genetic manipulation of schistosomes. Transgenesis mediated by mobile genetic elements offers a potentially tractable route to introduce foreign genes to schistosomes, a means to determine the importance of schistosome genes, including those that could be targeted in novel interventions and the potential to undertake large-scale forward genetics by insertional mutagenesis.
机译：曼氏血吸虫和日本血吸虫的基因组序列草案现已上市。然而，大多数血吸虫基因的身份和重要性尚未确定。最近，在血吸虫的遗传操纵和转基因方面已经取得进展。根据过去5年的发现，在血吸虫中功能丧失和功能获得方法似乎都是可行的。这篇综述集中在血吸虫转基因的报道，特别是那些涉及利用外源移动遗传元件和/或其内源亲戚对血吸虫的转化进行血吸虫的遗传操纵的报道。由移动遗传元件介导的转基因提供了将外源基因引入血吸虫的潜在易处理的途径，这是确定血吸虫基因的重要性的手段，包括那些可能在新型干预措施中靶向的基因，以及通过插入诱变进行大规模正向遗传学的潜力。

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