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首页> 外文期刊>Parasitology >Involvement of the beta-adrenergic system in the cardiac chronic form of experimental Trypanosoma cruzi infection.
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Involvement of the beta-adrenergic system in the cardiac chronic form of experimental Trypanosoma cruzi infection.

机译：β-肾上腺素系统参与实验性克鲁索氏锥虫感染的心脏慢性形式。

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摘要

Changes in the cardiac beta-adrenergic system in early stages of Trypanosoma cruzi infection have been described. Here, we studied an early (135 days post-infection-p.i.) and a late stage (365 days p.i.) of the cardiac chronic form of the experimental infection (Tulahuen or SGO-Z12 strains), determining plasma epinephrine and norepinephrine levels, beta-receptor density, affinity and function, cardiac cAMP concentration and phosphodiesterase activity, cardiac contractility, and the presence of beta-receptor autoantibodies. Tulahuen-infected mice presented lower epinephrine and norepinephrine levels; lower beta-receptor affinity and density; a diminished norepinephrine response and higher cAMP levels in the early stage, and a basal contractility similar to non-infected controls in the early and augmented in the late stage. The Tulahuen strain induced autoantibodies with weak beta-receptor interaction. SGO-Z12-infected mice presented lower norepinephrine levels and epinephrine levels that diminished with the evolution of the infection; lower beta-receptor affinity and an increased density; unchanged epinephrine and norepinephrine response in the early and a diminished response in the late stage; higher cAMP levels and unchanged basal contractility. The SGO-Z12 isolate induced beta-receptor autoantibodies with strong interaction with the beta-receptors. None of the antibodies, however, acted a as beta-receptor agonist. The present results demonstrate that this system is seriously compromised in the cardiac chronic stage of T. cruzi infection.
机译：已经描述了克氏锥虫感染早期心脏β-肾上腺素系统的变化。在这里，我们研究了心脏慢性形式的实验性感染（图拉胡恩或SGO-Z12菌株）的早期感染（感染后135天）和晚期（感染后365天），确定血浆肾上腺素和去甲肾上腺素水平，β -受体密度，亲和力和功能，心脏cAMP浓度和磷酸二酯酶活性，心脏收缩力以及β受体自身抗体的存在。感染图拉胡恩的小鼠的肾上腺素和去甲肾上腺素水平较低;较低的β受体亲和力和密度;早期的去甲肾上腺素反应减弱和较高的cAMP水平，基础收缩力与早期未感染的对照组相似，而晚期则增强。 Tulahuen菌株诱导的自身抗体具有弱的β-受体相互作用。受SGO-Z12感染的小鼠的去甲肾上腺素和肾上腺素水平较低，随着感染的发展而降低;较低的β受体亲和力和增加的密度;早期肾上腺素和去甲肾上腺素的反应保持不变，而晚期则下降;较高的cAMP水平和不变的基础收缩力。 SGO-Z12分离物诱导了与β受体具有强相互作用的β受体自身抗体。但是，没有一种抗体充当β受体激动剂。目前的结果表明，该系统在克鲁氏锥虫感染的心脏慢性阶段严重受损。

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