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首页> 外文期刊>Parasitology >Intraerythrocytic Plasmodium falciparum utilize a broad range of serum-derived fatty acids with limited modification for their growth.
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Intraerythrocytic Plasmodium falciparum utilize a broad range of serum-derived fatty acids with limited modification for their growth.

机译：红细胞内恶性疟原虫利用多种血清来源的脂肪酸，对其生长进行有限的修饰。

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摘要

Plasmodium falciparum causes the most severe form of malaria. Utilization of fatty acids in serum is thought to be necessary for survival of this parasite in erythrocytes, and thus characterization of the parasite fatty acid metabolism is important in developing a new strategy for controlling malaria. Here, we examined which combinations of fatty acids present in human serum support the continuous culture of P. falciparum in serum-free medium. Metabolic labelling and gas chromatography analyses revealed that, despite the need for particular fatty acids for the growth of intraerythrocytic P. falciparum, it can metabolize a broad range of serum-derived fatty acids into the major lipid species of their membranes and lipid bodies. In addition, these analyses showed that the parasite's overall fatty acid composition reflects that of the medium, although the parasite has a limited capacity to desaturate and elongate serum-derived fatty acids. These results indicate that the Plasmodium parasite is distinct from most cells, which maintain their fatty acid composition by coordinating de novo biosynthesis, scavenging, and modification (desaturation and elongation).
机译：恶性疟原虫引起疟疾的最严重形式。血清中脂肪酸的利用被认为是该寄生虫在红细胞中生存所必需的，因此，寄生虫脂肪酸代谢的表征对于开发控制疟疾的新策略很重要。在这里，我们检查了人类血清中存在的哪些脂肪酸组合支持恶性疟原虫在无血清培养基中的连续培养。代谢标记和气相色谱分析显示，尽管红细胞内恶性疟原虫的生长需要特殊的脂肪酸，但它可以将多种血清来源的脂肪酸代谢成其膜和脂质体的主要脂质种类。此外，这些分析表明，尽管该寄生虫的去饱和和延长血清来源的脂肪酸的能力有限，但其总脂肪酸组成反映了培养基的组成。这些结果表明，疟原虫的寄生虫不同于大多数细胞，它们通过协调从头进行的生物合成，清除和修饰（去饱和和伸长）来维持其脂肪酸组成。

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