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首页> 外文期刊>Parasitology >Effect of Plasmodium yoelii nigeriensis infection on hepatic and splenic glutathione-S-transferase(s) in Swiss albino and db/+ mice: efficacy of mefloquine and menadione in antimalarial chemotherapy.
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Effect of Plasmodium yoelii nigeriensis infection on hepatic and splenic glutathione-S-transferase(s) in Swiss albino and db/+ mice: efficacy of mefloquine and menadione in antimalarial chemotherapy.

机译：约氏疟原虫感染对瑞士白化病和db / +小鼠肝和脾脏谷胱甘肽S-转移酶的影响：甲氟喹和甲萘醌在抗疟疾化疗中的功效。

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摘要

The present report deals with the status of hepatic and splenic glutathione-S-transferase (GST) activities in mice during experimental infection with Plasmodium yoelii nigeriensis and subsequent treatment of infected mice with mefloquine (Mf) and menadione (Md). The infection caused significant decline in the hepatic and splenic glutathione-S-transferase (GST) activities of albino and db/+ mice. The decline was observed in the levels of both cytosolic and microsomal GST(s) of liver and spleen in both types of mice. Intraperitoneal administration of mefloquine at a dose of 5 mg/kg and menadione at a dose of 100 mg/kg, twice daily from day 1 p.i. (day 0) until day 10, caused restoration in the levels of hepatic as well as splenic GST(s), albeit to varying degrees. Mf was able to suppress parasitaemia by day 5 in the case of albino mice and by day 3 in the case of db/+ mice but was unable to cure both types of mice completely. On the other hand, Md caused a delay in maturation of infection in both cases, but could not cure the mice.
机译：本报告涉及在实验性感染约氏疟原虫尼日利亚和随后用甲氟喹（Mf）和甲萘醌（Md）治疗感染小鼠期间，小鼠肝和脾谷胱甘肽S-转移酶（GST）活性的状况。感染导致白化病小鼠和db / +小鼠的肝和脾谷胱甘肽S-转移酶（GST）活性显着下降。在这两种类型的小鼠中，均观察到肝和脾的胞浆和微粒体GST水平下降。从第1天开始每天两次腹膜内注射甲氟喹5 mg / kg，甲萘醌100 mg / kg。 （第0天）到第10天，尽管不同程度地引起肝和脾GST水平的恢复。 Mf能够在白化病小鼠的第5天和db / +小鼠的第3天抑制寄生虫血症，但不能完全治愈两种类型的小鼠。另一方面，在两种情况下，Md均会导致感染成熟延迟，但无法治愈小鼠。

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