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首页> 外文期刊>Parasitology >C.V.a The migration of Ascaris suum larvae, and the associated pulmonary inflammatory response in susceptible C57BL/6j and resistant CBA/Ca mice
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C.V.a The migration of Ascaris suum larvae, and the associated pulmonary inflammatory response in susceptible C57BL/6j and resistant CBA/Ca mice

机译：C.V.a在易感C57BL / 6j和耐药CBA / Ca小鼠中A虫幼虫的迁移以及相关的肺部炎症反应

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Ascariasis is an important infection in humans (Ascaris lumbricoides) and pigs (Ascaris suum) and individuals appear to be predisposed to either heavy or light worm burdens. These extremes of susceptibility and resistance are represented in a mouse model by 2 strains of mice, CBA mice showing high resistance to infection and C57BL/6 which are highly susceptible, as reflected in worm burdens in the lungs 6-7 days after infection. In an attempt to identify the point at which the difference between these 2 strains is first manifested, we quantified worm burdens at key stages during infection leading up to the pulmonary stage of development. Thus mice were inoculated with fully embryonated A. suum eggs and larval burdens were enumerated in the large intestine and rectum, liver and lungs of the 2 strains at 6 h post-inoculation (p.i.) and on each of days 1-8 p.i. inclusively. A higher percentage of the total inoculum was recovered from the intestine/rectum of C57BL/6j mice in contrast to CBA/Ca mice at 6 h p.i. Larvae were recovered from the intestinal contents and also whilst actively migrating through the large intestinal wall. The number of larvae recovered was significantly reduced in CBA/Ca mice in contrast to C57BL/6j mice between the phase of migration from the liver and arrival in the lungs. The combined results of the inoculation of mice with corticosteroids and the examination of the change in profile and number of leukocytes present in bronchoalveolar lavage fluid suggested that the pulmonary inflammatory immune response was not prominently involved in primary protection of mice to A. suum infection in the latter days of infection in the lungs. The susceptible C57BL/6j mice produced a BAL response almost twice as intense as that of resistant CBA/Ca mice with stronger neutrophil, lymphocyte and eosinophil but not macrophage components, suggesting that the difference in worm burdens between the strains was generated earlier in the course of infection. These results were further corroborated by a histological examination of the lung tissues which showed that the passage of the larval stages of A. suum through the mouse lungs was associated with a marked inflammatory response in both strains. Again, C57BL/6j mice exhibited increased inflammation relative to CBA/Ca mice. Hence some hepatic/post-hepatic factor that varies between the 2 strains, but exerts its effect before the lung phase plays a critical role in determining the success of larvae through the host tissues. The possible sites of this host defence are reviewed. 2007 Cambridge University Press.
机译：c虫病是人（Ascaris lumbricoides）和猪（Ascaris suum）的重要感染，个体似乎易患蠕虫沉重负担。这些极度的敏感性和耐药性在小鼠模型中表现为2种小鼠，其中CBA小鼠表现出对感染的高抗性，而C57BL / 6则具有高度易感性，反映在感染后6-7天的肺部蠕虫负担中。为了确定这两个菌株之间首先出现差异的点，我们量化了感染过程中直至肺部发育阶段关键阶段的蠕虫负担。因此，在小鼠接种后6小时和下午1-8天的每一天，给小鼠接种完全胚芽的A. suum卵，并在这两种毒株的大肠和直肠，肝和肺中计数幼虫负担。包括在内。与CBA / Ca小鼠在6 h p.i相比，从C57BL / 6j小鼠的肠/直肠中回收的总接种物百分比更高。幼虫从肠内容物中回收，并同时积极地通过大肠壁迁移。与C57BL / 6j小鼠相比，在从肝脏迁移到到达肺部的阶段，在CBA / Ca小鼠中回收的幼虫数量显着减少。皮质类固醇疫苗接种小鼠的结果以及支气管肺泡灌洗液中白细胞的分布和数量的变化的综合检查结果表明，肺炎性免疫应答并未明显参与小鼠对A. suum感染的初级保护。在肺部感染的后期。易感的C57BL / 6j小鼠产生的BAL反应强度几乎是具有更强嗜中性粒细胞，淋巴细胞和嗜酸性粒细胞但没有巨噬细胞成分的抗性CBA / Ca小鼠的两倍，这表明该过程之间较早产生了蠕虫负担的差异感染。肺组织的组织学检查进一步证实了这些结果，结果表明，两种菌株中猪肺孢子虫幼虫阶段通过小鼠肺部均与明显的炎症反应有关。再次，相对于CBA / Ca小鼠，C57BL / 6j小鼠表现出增加的炎症。因此，一些肝/肝后因子在两种菌株之间变化，但是在肺阶段在确定幼虫通过宿主组织的成功中起关键作用之前发挥作用。审查了此主机防御的可能站点。 2007剑桥大学出版社。

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