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首页> 外文期刊>Parasitology >Applying predator-prey theory to modelling immune-mediated, within-host interspecific parasite interactions.
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Applying predator-prey theory to modelling immune-mediated, within-host interspecific parasite interactions.

机译：应用捕食者－猎物理论对免疫介导的宿主内部种间寄生虫相互作用进行建模。

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摘要

Predator-prey models are often applied to the interactions between host immunity and parasite growth. A key component of these models is the immune system's functional response, the relationship between immune activity and parasite load. Typically, models assume a simple, linear functional response. However, based on the mechanistic interactions between parasites and immunity we argue that alternative forms are more likely, resulting in very different predictions, ranging from parasite exclusion to chronic infection. By extending this framework to consider multiple infections we show that combinations of parasites eliciting different functional responses greatly affect community stability. Indeed, some parasites may stabilize other species that would be unstable if infecting alone. Therefore hosts' immune systems may have adapted to tolerate certain parasites, rather than clear them and risk erratic parasite dynamics. We urge for more detailed empirical information relating immune activity to parasite load to enable better predictions of the dynamic consequences of immune-mediated interspecific interactions within parasite communities.
机译：捕食者－猎物模型通常应用于宿主免疫力和寄生虫生长之间的相互作用。这些模型的关键组成部分是免疫系统的功能反应，免疫活性和寄生虫负荷之间的关系。通常，模型采用简单的线性功能响应。但是，基于寄生虫与免疫力之间的机械相互作用，我们认为其他形式的可能性更大，导致从寄生虫排斥到慢性感染的预测非常不同。通过扩展此框架以考虑多种感染，我们表明引起不同功能反应的寄生虫组合极大地影响了社区的稳定性。确实，某些寄生虫可能会使其他物种稳定下来，而这些物种如果单独感染会不稳定。因此，宿主的免疫系统可能已经适应了某些寄生虫，而不是清除它们并冒着不稳定的寄生虫动态的危险。我们敦促获得更详细的经验信息，将免疫活性与寄生虫负荷相关联，以更好地预测寄生虫群落中免疫介导的种间相互作用的动态后果。

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