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首页> 外文期刊>Parasitology >Rates and intensity of re-infection with human helminths after treatment and the influence of individual, household, and environmental factors in a Brazilian community.
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Rates and intensity of re-infection with human helminths after treatment and the influence of individual, household, and environmental factors in a Brazilian community.

机译:在巴西社区中,经过治疗后再感染人类蠕虫的速度和强度,以及个人,家庭和环境因素的影响。

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This study quantifies the rate and intensity of re-infection with human hookworm and Schistosoma mansoni infection 12 months following successful treatment, and investigates the influence of socio-economic, geographical and environmental factors. A longitudinal study of 642 individuals aged over 5 years was conducted in Minas Gerais State, Brazil from June 2004 to March 2006. Risk factors were assessed using interval censored regression for the rate and negative binomial regression for intensity. The crude rate and intensity of hookworm re-infection was 0.21 per year (95% confidence interval (CI) 0.15-0.29) and 70.9 epg (95% CI 47.2-106.6). For S. mansoni the rate was 0.06 per year (95% CI 0.03-0.10) and intensity 6.51 epg (95% CI 3.82-11.11). Rate and intensity of re-infection with hookworm were highest among males and positively associated with previous infection status, absence of a toilet and house structure. Rate and intensity of S. mansoni re-infection were associated with previous infection status as well as geographical, environmental and socio-economic factors. The implications of findings for the design of anti-helminth vaccine trials are discussed.
机译:这项研究量化了成功治疗后12个月人类钩虫和曼氏血吸虫感染的再感染率和强度,并调查了社会经济,地理和环境因素的影响。 2004年6月至2006年3月,在巴西的米纳斯吉拉斯州对642名5岁以上的人进行了纵向研究。使用区间删失率作为回归指标,对风险进行二项式回归,对风险因素进行了评估。钩虫再感染的粗率和强度为每年0.21(95%置信区间(CI)0.15-0.29)和70.9 epg(95%CI 47.2-106.6)。曼氏葡萄球菌的发病率为每年0.06(95%CI为0.03-0.10),强度为6.51 epg(95%CI为3.82-11.11)。男性钩虫再感染率和强度最高,与以前的感染状况,缺乏厕所和房屋结构成正相关。曼氏沙门氏菌再感染的速度和强度与以前的感染状况以及地理,环境和社会经济因素有关。讨论了研究结果对抗蠕虫疫苗试验设计的意义。

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