...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Parasitology >cAMP-dependent protein kinase from Plasmodium falciparum: an update.
【24h】

cAMP-dependent protein kinase from Plasmodium falciparum: an update.

机译：来自恶性疟原虫的cAMP依赖性蛋白激酶：一项更新。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

One of the most important public health problems in the world today is the emergence and dissemination of drug-resistant malaria parasites. Plasmodium falciparum is the causative agent of the most lethal form of human malaria. New anti-malarial strategies are urgently required, and their design and development require the identification of potential therapeutic targets. However, the molecular mechanisms controlling the life cycle of the malaria parasite are still poorly understood. The published genome sequence of P. falciparum and previous studies have revealed that several homologues of eukaryotic signalling proteins, such as protein kinases, are relatively conserved. Protein kinases are now widely recognized as important drug targets in protozoan parasites. Cyclic AMP-dependent protein kinase (PKA) is implicated in numerous processes in mammalian cells, and the regulatory mechanisms of the cAMP pathway have been characterized. P. falciparum cAMP-dependent protein kinase plays an important role in the parasite's life cycle and thus represents an attractive target for the development of anti-malarial drugs. In this review, we focus on the P. falciparum cAMP/PKA pathway to provide new insights and an improved understanding of this signalling cascade.
机译：当今世界上最重要的公共卫生问题之一是耐药性疟疾寄生虫的出现和传播。恶性疟原虫是人类疟疾最致命形式的病原。迫切需要新的抗疟疾策略，其设计和开发需要确定潜在的治疗靶标。然而，控制疟原虫生命周期的分子机制仍然知之甚少。恶性疟原虫的已公开基因组序列和先前的研究表明，真核信号蛋白的几个同源物，例如蛋白激酶，相对保守。现在，蛋白激酶已被广泛认为是原生动物寄生虫的重要药物靶标。环状AMP依赖性蛋白激酶（PKA）与哺乳动物细胞的许多过程有关，并且已经表征了cAMP途径的调控机制。恶性疟原虫cAMP依赖性蛋白激酶在寄生虫的生命周期中起重要作用，因此代表了抗疟药开发的有吸引力的靶标。在这篇综述中，我们着重于恶性疟原虫cAMP / PKA途径，以提供新的见解和对这种信号级联反应的更好理解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号