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首页> 外文期刊>Parasitology >Diphenyl diselenide and sodium selenile associated with chemotherapy in experimental toxoplasmosis: influence on oxidant/antioxidant biomarkers and cytokine modulation
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Diphenyl diselenide and sodium selenile associated with chemotherapy in experimental toxoplasmosis: influence on oxidant/antioxidant biomarkers and cytokine modulation

机译：二苯二硒化物和亚硒酸钠与弓形虫病化疗的关系：对氧化剂/抗氧化剂生物标志物和细胞因子调节的影响

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The aim of this study was to assess the effect of sulfamcthoxazolc/trimethoprim (ST) supplemented with diphenyl diselenide and sodium selenite in experimental toxoplasmosis, on oxidant/antioxidant biomarkers and cytokine levels. Eighty-four BALB/c mice were divided in seven groups: group A (negative control), and groups B to G (infected). Blood and liver samples were collected on days 4 and 20 post infection (p.i.). Levels of thiobarbituric acid (TBA) reactive substances and advanced oxidation protein products (AOPP) were assessed in liver samples. Both biomarkeis were significantly increased in infected groups on day 4 p.i., while they were reduced on day 20 p.i., compared with group A. Glutathione reductase (GR) activity significantly (P<001) increased on day 4 p.i., in group G, compared with group A. INF-gamma was significantly increased (P<0.001) in both periods, day 4 (groups B, C, F and G) and 20 p.i. (groups C, F and G). IL-10 significantly reduced (P< 0.001) on day 4 p.i. in group B; however, in the same period, it was increased (P< 0.001) in groups C and G, compared with group A. On day 20 p.i., IL-10 increased (P<0.001) in groups F and G. Therefore, our results highlighted that these forms of selenium, associated with the chemotherapy, were able to reduce lipid peroxidation and protein oxidation, providing a beneficial immunological balance between the production of pro- and anti-inflammatory cytokines.
机译：这项研究的目的是评估在实验弓形虫病中补充联苯二硒化物和亚硒酸钠的磺胺甲恶唑/甲氧苄啶（ST）对氧化剂/抗氧化剂生物标志物和细胞因子水平的影响。将八十四只BALB / c小鼠分为七组：A组（阴性对照组）和B至G组（感染）。在感染后第4天和第20天（p.i.）收集血液和肝脏样本。在肝脏样品中评估了硫代巴比妥酸（TBA）反应性物质和高级氧化蛋白产物（AOPP）的水平。与A组相比，感染组在第4天时两种生物标志物均显着增加，而在第20天时它们均降低。在G组，第4天时谷胱甘肽还原酶（GR）活性显着增加（P <001）在第4天（B，C，F和G组）和20 pi的两个时期中，INF-γ均显着升高（P <0.001）。 （C，F和G组）。 IL-10在p.i第4天显着降低（P <0.001）。 B组然而，在同一时期，C和G组的血友病率较A组增加（P <0.001）。在第20天的pi，IL-10在F和G组的发病率增加（P <0.001）。因此，我们的结果着重指出，这些形式的硒与化学疗法有关，能够减少脂质过氧化和蛋白质氧化，从而在促炎和抗炎细胞因子的产生之间提供有益的免疫平衡。

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