Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

DonR.; IosetJ.-R.

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Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

机译：筛选策略以确定新的化学多样性，以开发用于治疗运动质体感染的药物

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SUMMARY The Drugs for Neglected Diseases initiative (DNDi) has defined and implemented an early discovery strategy over the last few years, in fitting with its virtual R&D business model. This strategy relies on a medium- to high-throughput phenotypic assay platform to expedite the screening of compound libraries accessed through its collaborations with partners from the pharmaceutical industry. We review the pragmatic approaches used to select compound libraries for screening against kinetoplastids, taking into account screening capacity. The advantages, limitations and current achievements in identifying new quality series for further development into preclinical candidates are critically discussed, together with attractive new approaches currently under investigation.

机译：总结过去几年中，被忽视疾病药物计划（DNDi）与其虚拟R＆D业务模型相适应，已定义并实施了一项早期发现策略。该策略依赖于中至高通量的表型分析平台，以加快与通过与制药行业合作伙伴合作访问的化合物库的筛选。我们回顾了考虑筛选能力的实用方法，用于选择化合物文库筛选针对运动质体。严格讨论了鉴定新质量系列以进一步发展为临床前候选药物的优势，局限性和当前成就，以及目前正在研究的有吸引力的新方法。

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《Parasitology》 |2014年第1期|共7页
作者
DonR.; IosetJ.-R.;
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正文语种 eng
中图分类寄生虫病;
关键词
Chagas' disease; DNDi; high-content; High-throughput; human African trypanosomiasis; Leishmaniasis; library selection; screening;

机译：查加斯病;DNDi;高含量;高通量;人类非洲锥虫病;利什曼病;图书馆选择;筛选;

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1. Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections [J] . DonR., IosetJ.-R. Parasitology . 2014,第1期

机译：筛选策略以确定新的化学多样性，以开发用于治疗运动质体感染的药物
2. Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis [J] . Murakami G., Inoue H., Tsukita K., Journal of biomolecular screening: The official journal of the Society for Biomolecular Screening . 2011,第4期

机译：化学文库筛选鉴定出一种小分子，该小分子下调用于治疗肌萎缩性侧索硬化症的药物的SOD1转录
3. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. [J] . Xiuning Le, Emily K Pugach, Simone Hettmer, Development . 2013,第11期

机译：斑马鱼中一种新颖的化学筛选策略可确定胚胎发生和横纹肌肉瘤发展中的常见途径。
4. A MASS SPECTROMETRY BASED ASSAY TO IDENTIFY NEW LEAD COMPOUNDS AGAINST DRUG RESISTANT BACTERIAL INFECTIONS [C] . Daniel A. Todd, David B. Zich, Alexander R. Horswill, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：基于质谱的基于质谱法，以鉴定抗耐药细菌感染的新铅化合物
5. Part I. Development of new organic synthetic methods: Palladium and copper catalyzed carbon-carbon, carbon-sulfur, carbon-nitrogen, and carbon-oxygen bond formation as well as DABCO-mediated stereospecific synthesis of acrylate ethers and amines. Part II. Design, synthesis and SAR studies of new classes of agents to treat drug-resistant bacteria, anthrax and tuberculosis infections. [D] . Kabir, Mohd Shahjahan. 2011

机译：第一部分：新的有机合成方法的开发：钯和铜催化的碳-碳，碳-硫，碳-氮和碳-氧键的形成，以及DABCO介导的丙烯酸酯醚和胺的立体有择合成。第二部分新型药物的设计，合成和SAR研究，用于治疗抗药性细菌，炭疽和肺结核感染。
6. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development [O] . Xiuning Le, Emily K. Pugach, Simone Hettmer, -1

机译：斑马鱼中一种新颖的化学筛选策略可确定胚胎发生和横纹肌肉瘤发展的常见途径
7. Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections – CORRIGENDUM [O] . 2013

机译：筛选策略，以识别药物开发的新化学多样性，以治疗KINETOPETID感染 - 勘误

Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

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