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首页> 外文期刊>Parasitology Research >Molecular characterizations of an inhibitor of apoptosis from Schistosoma japonicum.
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Molecular characterizations of an inhibitor of apoptosis from Schistosoma japonicum.

机译:日本血吸虫的凋亡抑制剂的分子特征。

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摘要

Apoptosis is a normal process for regulating cellular death of many organisms. Here, we molecularly characterized an inhibitor of apoptosis from Schistosoma japonicum (SjIAP). The transcription of the SjIAP predominantly occurred at the developmental stages in a final host. Functional assay indicated that the SjIAP could inhibit caspase activity either in 293T cell or in schistosome lysates. Additionally, there were differently expressed profiles of the SjIAP in S. japonicum living in different hosts. Our preliminary results suggest that the SjIAP may play important roles in parasitic living and development as well as in the host-parasite interactions, and drug target of SjIAP might be a potential for controlling schistosomiasis.
机译:凋亡是调节许多生物的细胞死亡的正常过程。在这里,我们在分子上表征了日本血吸虫(SjIAP)的凋亡抑制剂。 SjIAP的转录主要发生在最终宿主的发育阶段。功能测定表明,SjIAP可以抑制293T细胞或血吸虫裂解液中的caspase活性。另外,生活在不同宿主中的日本血吸虫中SjIAP的表达谱也不同。我们的初步结果表明,SjIAP可能在寄生虫的生活和发展以及宿主与寄生虫的相互作用中起重要作用,而SjIAP的药物靶标可能是控制血吸虫病的潜力。

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