Mucoadhesive polymers with immobilized proteinase inhibitors for oral administration of protein drugs.

Plate NA; Valuev IL; Sytov GA; Valuev LI

首页> 外文期刊>Biomaterials >Mucoadhesive polymers with immobilized proteinase inhibitors for oral administration of protein drugs.

【24h】

Mucoadhesive polymers with immobilized proteinase inhibitors for oral administration of protein drugs.

机译：具有固定化蛋白酶抑制剂的粘膜粘附聚合物，用于口服口服蛋白药物。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A new approach to overcome the degradation of protein drugs by proteolytic enzymes and their targeting to the blood through the digestive apparatus was developed. The approach is based on the immobilization of drugs into the polymeric hydrogel containing glycoprotein--ovomucoid from duck egg whites. This glycoprotein inhibits the activity of proteolytic enzymes and acts as a biospecific ligand to lectins on the walls of the gastrointestinal tract.

机译：开发了一种新的方法来克服蛋白药物被蛋白水解酶降解以及通过消化装置将其靶向血液的问题。该方法基于将药物固定在鸭蛋白中含有糖蛋白-卵类粘液的聚合物水凝胶中。该糖蛋白抑制蛋白水解酶的活性，并充当胃肠道壁上凝集素的生物特异性配体。

著录项

来源
《Biomaterials》 |2002年第7期|共5页
作者
Plate NA; Valuev IL; Sytov GA; Valuev LI;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医用一般科学;
关键词
Proteins; inhibitors; Polymers; Endopeptidases; Peptide Hydrolases; 蛋白质类; 聚合物; 肽水解酶类;

机译：Proteins;inhibitors;Polymers;Endopeptidases;Peptide Hydrolases;蛋白质类;聚合物;肽水解酶类;

相似文献

外文文献
中文文献
专利

1. Mucoadhesive polymers with immobilized proteinase inhibitors for oral administration of protein drugs. [J] . Plate NA, Valuev IL, Sytov GA, Biomaterials . 2002,第7期

机译：具有固定化蛋白酶抑制剂的粘膜粘附聚合物，用于口服口服蛋白药物。
2. Design and evaluation of a nanoparticulate system prepared by biodegradable polymers for oral administration of protein drugs. [J] . Sahu SK, Prusty AK Die Pharmazie . 2010,第11期

机译：由可生物降解的聚合物制备的用于蛋白质药物口服的纳米颗粒系统的设计和评估。
3. Design and evaluation of a nanoparticulate system prepared by biodegradable polymers for oral administration of protein drugs. [J] . Sahu SK, Prusty AK Die Pharmazie . 2010,第11期

机译：可生物降解聚合物制备的纳米颗粒体系的设计与评价，用于口服蛋白质药物。
4. BIOADHESIVE GRADUALLY DISSOLVED POLYMERIC FILMS WITH PROTEINASE INHIBITORS FOR TOPICAL DELIVERY [C] . I.P. Gladysheva, N.A. Moroz, N.G. Balabushevitch, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：具有蛋白质抑制剂的生物降解型梯度溶解高分子薄膜，用于局部递送
5. Effects of corn pollen chemistry, dietary proteinase inhibitors and beetle oral secretions on feeding behaviors and fecundity of adult western corn rootworm. [D] . Kim, Jae Hak. 2002

机译：玉米花粉化学成分，饮食蛋白酶抑制剂和甲虫口腔分泌物对成年西部玉米根虫的摄食行为和繁殖力的影响。
6. Enhanced Mucoadhesive Capacity of Novel Co-polymers for Oral Protein Delivery [O] . F. Michael Marks, Anthony Lowman -1

机译：增强新型共聚物的粘膜粘附能力用于口服蛋白质递送
7. Amine-functionalization of glycidyl methacrylate-containing emulsion-templated porous polymers and immobilization of proteinase K for biocatalysis. [O] . Kimmins Scott D., Wyman Paul, Cameron Neil R. 2014

机译：含甲基丙烯酸缩水甘油酯的乳液模板多孔聚合物的胺功能化和蛋白酶K的固定化，以进行生物催化。

Mucoadhesive polymers with immobilized proteinase inhibitors for oral administration of protein drugs.

摘要

著录项

相似文献

相关主题

期刊订阅