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首页> 外文期刊>Biomaterials >Immobilization of a nonsteroidal antiinflammatory drug onto commercial segmented polyurethane surface to improve haemocompatibility properties.
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Immobilization of a nonsteroidal antiinflammatory drug onto commercial segmented polyurethane surface to improve haemocompatibility properties.

机译：将非甾体类抗炎药固定在商业化的分段聚氨酯表面上，以改善血液相容性。

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摘要

A method has been developed in which a layer of p-aminosalicylic acid (4-amino-2-hydroxybenzoic acid) (PAS), a water soluble pharmaceutical compound of the nonsteroidal anti-inflammatory drug (NSAID) class with antiaggregant platelet activity, is covalently immobilized onto a segmented polyurethane, Biospan (SPU) surface. Thus, SPU surfaces were modified by grafting of hexamethylenediisocyanate. and the free isocyanate remaining on the SPU surface were then coupled through a condensation reaction to amine groups of p-aminosalicylic acid. The bonding of PAS from aqueous solution onto SPU surface was studied by ATR-FTIR. UV and fluorescence spectroscopy. Plateau levels of coupled PAS were reached within 1.2 microg/cm2 using PAS solution concentrations of 1mg/ ml. The surface wettability of the polymeric films measured by contact angle indicate that the introduction of the PAS turns the surface more hydrophilic (theta(water) = 43.1 +/- 2.1) relatively to the original SPU films (theta(water) = 70.3 +/- 1.9). The in vitro albumin (BSA) adsorption shows that the PAS-SPU films adsorb more BSA (250/microgmm2) than the original SPU (112 microg mm2). Thrombogenicity was assessed by measuring the thrombus formation and platelet adhesion of the SPU containing PAS relatively to nonmodified SPU surfaces. The polymeric surfaces with immobilized PAS had better nonthrombogenic characteristics as indicated by the low platelet adhesion, high adsorption of albumin relatively to fibrinogen and low thrombus formation, making them potentially good candidates for biomedical applications.
机译：已经开发出一种方法，其中一层对氨基水杨酸（4-氨基-2-羟基苯甲酸）（PAS）是一种具有抗凝集血小板活性的非甾体抗炎药（NSAID）类的水溶性药物化合物。共价固定在分段的聚氨酯Biospan（SPU）表面上。因此，通过接枝六亚甲基二异氰酸酯对SPU表面进行了改性。然后通过缩合反应将残留在SPU表面上的游离异氰酸酯与对氨基水杨酸的胺基偶联。通过ATR-FTIR研究了PAS从水溶液到SPU表面的键合。紫外和荧光光谱。使用浓度为1mg / ml的PAS溶液，偶联的PAS的稳定水平达到1.2 microg / cm2。通过接触角测量的聚合物膜的表面润湿性表明，相对于原始SPU膜（θ（水）= 70.3 + /），引入PAS可使表面变得更亲水（θ（水）= 43.1 +/- 2.1）。 -1.9）。体外白蛋白（BSA）吸附表明，PAS-SPU膜比原始SPU（112 microg mm2）吸附更多的BSA（250 / microgmm2）。通过测量相对于未修饰的SPU表面的含PAS的SPU的血栓形成和血小板粘附来评估血栓形成性。固定的PAS的聚合物表面具有更好的非血栓形成特性，这表现为血小板粘附力低，白蛋白相对于纤维蛋白原的吸附性高以及血栓形成少，使其成为生物医学应用的潜在候选者。

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