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首页> 外文期刊>Parasitology Today >Schistosomiasis Vaccines: a devils' advocate view
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Schistosomiasis Vaccines: a devils' advocate view

机译：血吸虫病疫苗：恶魔的倡导者观点

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Schistosomiasis is one of the most prevalent and complex parasites of humans. For decades, scientists have been fascinated by the immunological determinants of schistosomiasis, fostering hope that a vaccine could eventually be developed. As testified by recent issues of Parasitology Today, this quest is more alive than ever, immunological, epidemiological and biotechnological developments have led to new hopes and daring advances. Promising results in animal models have been reported with a series of antigens, although in an independent test, none of them accomplished the pre-set target level of 40% protection. Many questions remain, and alternative strategies are still being explored. Nevertheless, an international gathering of scientists accepted the move from research to vaccine development, and 'showed eagerness to learn more about immune responses to vaccine candidates through controlled human trials. At the very least, a schistosomiasis vaccine is considered 'feasible and desirable. Production under good manufacturing practice, followed by clinical trials, has been recommended for four molecules, and has already been achieved for one of them.
机译：血吸虫病是人类最普遍和最复杂的寄生虫之一。几十年来，科学家一直对血吸虫病的免疫学决定因素着迷，这激发了人们希望最终开发出疫苗的希望。正如今天《寄生虫学》最近一期所证明的那样，这一追求比以往任何时候都更加活跃，免疫，流行病学和生物技术的发展带来了新的希望和大胆的进步。在动物模型中有一系列抗原的结果令人鼓舞，尽管在一项独立测试中，它们都没有达到预设的40％保护目标水平。仍然存在许多问题，替代策略仍在探索中。尽管如此，一个国际科学家聚会接受了从研究到疫苗开发的转变，并表示渴望通过受控的人体试验来了解更多有关对候选疫苗的免疫反应的信息。至少，血吸虫病疫苗被认为是“可行且合乎需要的”。建议在良好的生产规范下进行生产，然后进行临床试验，以生产四种分子，并且其中一种已经实现。

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