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ANALYSIS OF IN VIVO IMMUNE RESPONSES DURING TOXOPLASMA GONDII INFECTION USING THE TECHNIQUE OF LYMPHATIC CANNULATION

机译:淋巴插管技术分析弓形虫感染期间的体内免疫反应

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摘要

A major obstacle in the design of effective inactivated vaccines is the induction of an appropriate immune response in the recipient Direct examination of immune responses induced in vivo following infection is possible using the technique of lymphatic cannulation. This allows a unique insight into the development of the immune response to Particular pathogens and provides important information that could be exploited in the design of suitable vaccine delivery systems in order to induce and maintain appropriate protective immune responses. In this article, Elisabeth Innes and Jonathan Wastling review studies involving the use of lymphatic cannulation to examine immune responses induced in vivo during infection of sheep with the S48 strain of Toxoplasma gondii, which is currently used as a vaccine against toxoplasmosis for veterinary use only.
机译:设计有效的灭活疫苗的主要障碍是在受体中诱导适当的免疫反应。使用淋巴插管技术可以直接检查感染后体内诱导的免疫反应。这提供了对特定病原体免疫应答发展的独特见解,并提供了重要信息,可在设计合适的疫苗输送系统时利用这些信息,以诱导和维持合适的保护性免疫应答。在本文中,伊丽莎白·英尼斯(Elisabeth Innes)和乔纳森·沃斯汀(Jonathan Wastling)进行了回顾性研究,涉及使用淋巴管插管检查在绵羊感染弓形虫S48株S48株的过程中在体内诱导的免疫反应,目前仅将其用作抗弓形虫病疫苗用于兽医。

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