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首页> 外文期刊>Parkinsonism & related disorders >The association between motor subtypes and psychopathology in Parkinson's disease.
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The association between motor subtypes and psychopathology in Parkinson's disease.

机译：运动亚型与帕金森氏病的心理病理学之间的关联。

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BACKGROUND: In Parkinson's disease (PD) it has been suggested that various motor subtypes are also characterized by a different prevalence and severity of specific non-motor symptoms such as cognitive deterioration, depression, apathy and hallucinations. The aim of this study was to investigate the association between motor subtypes and psychopathology in PD. METHODS: An exploratory and confirmatory cluster analysis of motor and psychopathological symptoms was performed with a randomized sample of 173 patients each, stemming from two research databases: one from Stavanger University Hospital and one from Maastricht University Hospital. These databases contained data of standardized assessments of patients with the Unified Parkinson's Disease Rating Scale, the Montgomery-Asberg Depression Rating Scale, and the Mini-Mental State Examination. RESULTS: PD patients can be accurately and reliably classified into four different subtypes: rapid disease progression subtype, young-onset subtype, non-tremor-dominant subtype with psychopathology and a tremor-dominant subtype. Cognitive deterioration, depressive and apathetic symptoms, and hallucinations all cluster within the non-tremor-dominant motor subtype, that is characterized by hypokinesia, rigidity, postural instability and gait disorder. CONCLUSIONS: This study shows that non-tremor-dominant PD is associated with cognitive deterioration, depression, apathy, and hallucinations, which has implications for future research into the pathophysiology of psychopathology in PD.
机译：背景：在帕金森氏病（PD）中，已提出各种运动亚型的特征还在于特定非运动症状（如认知能力下降，抑郁，冷漠和幻觉）的患病率和严重程度不同。这项研究的目的是调查PD的运动亚型和心理病理之间的关联。方法：对运动和心理病理症状进行了探索性和证实性的聚类分析，每个患者随机抽取173名患者，来自两个研究数据库：一个来自斯塔万格大学医院，一个来自马斯特里赫特大学医院。这些数据库包含帕金森病综合评分量表，蒙哥马利-阿斯伯格抑郁量表和迷你精神状态检查患者的标准化评估数据。结果：PD患者可以准确可靠地分为四种不同的亚型：疾病进展快速亚型，年轻发病亚型，心理病理学上非震颤为主的亚型和震颤为主的亚型。认知衰退，抑郁和无情症状以及幻觉都集中在非震颤主导型运动亚型中，该运动亚型的特征在于运动不足，僵硬，姿势不稳和步态障碍。结论：这项研究表明，非震颤为主的PD与认知能力下降，抑郁，冷漠和幻觉有关，这对PD的心理病理学病理生理学的未来研究具有重要意义。

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