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首页> 外文期刊>Parkinsonism & related disorders >Reduced thalamic volume in Parkinson disease with REM sleep behavior disorder: Volumetric study
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Reduced thalamic volume in Parkinson disease with REM sleep behavior disorder: Volumetric study

机译：帕金森病伴快速眼动睡眠行为障碍者丘脑容量减少：容量研究

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Introduction: REM sleep behavior disorder (RBD) is a common non motor feature of Parkinson's Disease (PD) affecting about half the patients with this disease. Distinct structural brain tissue abnormalities have been reported in several regions modulating REM sleep of the patients with idiopathic RBD. At the present time, there are no conventional MRI studies investigating patients with PD associated with RBD. Methods: Herein, we used voxel-based morphometry (VBM) to detect the neuroanatomical profile of PD patients with and without RBD. Optimized VBM was applied to the MRI brain images in 11 PD patients with RBD (PD-RBD), 11 PD patients without RBD (PD) and 18 age-and sex-matched controls. To corroborate VBM findings we used automated volumetric method (FreeSurfer) to quantify subcortical brain regions volumes. Patients and controls also underwent DAT-SPECT and cardiac MIBG scintigraphies. Results: The VBM analysis showed markedly reduced gray matter volume in the right thalamus of PD-RBD patients in comparison with PD patients and controls. Automatic thalamic segmentation in PD-RBD patients showed a bilaterally reduced thalamic volume as compared with PD patients or controls. All PD patients (with and without RBD) showed a reduced tracer uptake on DAT-SPECT and cardiac MIBG scintigraphies as compared to controls. Conclusions: Our findings suggest that the presence of RBD symptoms in PD patients is associated with a reduced thalamic volume suggesting a pathophysiologic role of the thalamus in the complex circuit causing RBD.
机译：简介：REM睡眠行为障碍（RBD）是帕金森氏病（PD）的常见非运动功能，影响约一半患有这种疾病的患者。在特发性RBD患者的多个REM调节区域中，已经报道了明显的结构性脑组织异常。目前，尚无常规的MRI研究来研究PD与RBD相关的患者。方法：在本文中，我们使用基于体素的形态计量学（VBM）检测有无RBD的PD患者的神经解剖学特征。优化的VBM应用于11例RBD（PD-RBD）的PD患者，11例无RBD（PD）的PD患者和18个年龄和性别匹配的对照的MRI脑图像。为了证实VBM的发现，我们使用了自动体积法（FreeSurfer）来量化皮层下大脑区域的体积。患者和对照还接受了DAT-SPECT和心脏MIBG闪烁显像。结果：VBM分析显示，与PD患者和对照组相比，PD-RBD患者右丘脑的灰质体积明显减少。与PD患者或对照组相比，PD-RBD患者的自动丘脑分割显示双侧丘脑体积减小。与对照组相比，所有PD患者（有和没有RBD）在DAT-SPECT和心脏MIBG闪烁显像仪上均显示出减少的示踪剂摄取。结论：我们的发现表明PD患者存在RBD症状与丘脑容量减少有关，提示丘脑在引起RBD的复杂回路中具有病理生理作用。

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