Trimolecular Condensation of Substituted Indoles with Paraformaldehyde and Meldrum's Acid. Convective Heating versus Microwave Irradiation: A Comparative Study

Csaba Nemes; Jean-Yves Laronze

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Trimolecular Condensation of Substituted Indoles with Paraformaldehyde and Meldrum's Acid. Convective Heating versus Microwave Irradiation: A Comparative Study

机译：用低聚甲醛和Meldrum酸取代吲哚的三分子缩合。对流加热与微波辐射的比较研究

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Results obtained in a comparative study on the trimolecular condensation of substituted indoles 1 with paraformaldehyde and Meldrum's acid using convective heating vs. microwave irradiation are described. Both methods afforded adducts 2 together with their hydroxymethylated derivatives 3 in good yields. Although in both cases the yields are about the same, the microwave irradiation was found to be more advantageous, as this procedure makes possible to considerably reduce the reaction times and to obtain cleaner reaction mixtures.

机译：描述了在对流加热与微波辐射下对取代的吲哚1与多聚甲醛和Meldrum酸进行三分子缩合的比较研究中获得的结果。两种方法均以高收率提供了加合物2及其羟甲基化衍生物3。尽管在两种情况下产率都差不多，但是发现微波辐射是更有利的，因为该程序可以大大减少反应时间并获得更清洁的反应混合物。

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《Synthesis: International Journal of Methods in Synthetic Organic Chemistry》 |1999年第2期|共4页
作者
Csaba Nemes; Jean-Yves Laronze;
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正文语种 eng
中图分类有机化学;
关键词
condensation; indole; Meldrum's acid; paraformaldehyde; microwave irradiation;

机译：缩合;吲哚;马德拉姆酸;低聚甲醛;微波辐射;

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1. Trimolecular Condensation of Substituted Indoles with Paraformaldehyde and Meldrum's Acid. Convective Heating versus Microwave Irradiation: A Comparative Study [J] . Csaba Nemes, Jean-Yves Laronze Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 1999,第2期

机译：用低聚甲醛和Meldrum酸取代吲哚的三分子缩合。对流加热与微波辐射的比较研究
2. Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating [J] . Cheng-Sheng Jia, Ze Zhang, Shu-Jiang Tu, Organic & biomolecular chemistry . 2006,第1期

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3. Cupric acetate catalysed alkylation of indoles in water: A comparative study between conventional heating and microwave irradiation [J] . C.Kathing, S.Tumtin, N.GSingh Organic chemistry: an Indian journal . 2013,第7期

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4. A comparative study on electrochemical synthesis of carboxylic acid substituted indoles and their application in selective oxidation of dopamine [C] . Vandana Singh, Dheeraj S. Chauhan, Prem C. Pandey IEEE Sensors Conference . 2009

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5. Comparative study of ossification induced by a synthetic bone-substitute material (beta-tricalcium phosphate) versus platelet-rich plasma in dogs. [D] . Kovacs, Katalin. 2004

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6. Comparative Kinetic Study and Microwaves Non-Thermal Effects on the Formation of Poly(amic acid) 44′-(Hexafluoroisopropylidene)diphthalic Anhydride (6FDA) and 44′-(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline (BAPHF). Reaction Activated by Microwave Ultrasound and Conventional Heating [O] . Hugo Mendoza Tellez, Joaquín Palacios Alquisira, Carlos Rius Alonso, 2011

机译：形成聚酰胺酸44-（六氟异亚丙基）二邻苯二甲酸酐（6FDA）和44-（六氟异亚丙基）双（对苯氧基）二苯胺（BAPHF）的比较动力学研究和微波非热效应。微波超声波和常规加热激活的反应
7. Meldrum's acid in organic synthesis. V. Versatile one-pot synthesis of indolepropionic esters via simultaneous condensation of three different carbon components, indole, aldehydes and Meldrum's acid. [O] . YUJI OIKAWA, HITOSHI HIRASAWA, OSAMU YONEMITSU 1982

机译：Meldrum的有机合成中的酸。 V.通过同时缩合三种不同的碳成分，吲哚，醛和meldrum酸，通过同时缩合通用一锅吲哚酯的合成。

Trimolecular Condensation of Substituted Indoles with Paraformaldehyde and Meldrum's Acid. Convective Heating versus Microwave Irradiation: A Comparative Study

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