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首页> 外文期刊>Pediatric nephrology: journal of the International Pediatric Nephrology Association >Frequent hemodialysis with NxStagetrade mark system in pediatric patients receiving maintenance hemodialysis.
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Frequent hemodialysis with NxStagetrade mark system in pediatric patients receiving maintenance hemodialysis.

机译：接受维持性血液透析的小儿患者，经常使用NxStagetrade标记系统进行血液透析。

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摘要

Recent evidence from adult hemodialysis (HD) patient studies reveal improved biochemical control and reported health-related quality of life after transition from conventional thrice weekly to daily home maintenance HD treatment. Published pediatric frequent dialysis experiences demonstrate similar improvement but all used conventional HD machines, which employ a treated municipal water supply, thereby frequently exposing patients to proinflammatory components. We report our pediatric experience with six-times-weekly HD using the NxStagetrade mark system, which uses sterile dialysis fluid to provide dialysis in the home or center setting. Four patients (weight range 38-61.4 kg) completed the 16-week study. Patients exhibited progressive reductions in casual pretreatment systolic and diastolic blood pressures, discontinuation of antihypertensive medications, and decreased blood pressure load by ambulatory blood pressure monitoring. Mean serum phosphorus improved without change in phosphorus binder medication, and all three patients with a normalized protein catabolic rate <1 g/kg per day at the beginning of the study improved to a normalized protein catabolic rate (nPCR) of >1.1 g/kg per day. Patients reported no adverse effects. Variable changes in proinflammatory cytokine levels were observed. We suggest that frequent HD with the NxStagetrade mark system be considered for children who would benefit from home-based maintenance dialysis.
机译：从成人血液透析（HD）患者研究获得的最新证据表明，从常规的每周三次转为每日家庭维护高清治疗后，生化控制得到改善，并报告了与健康相关的生活质量。已发表的儿科频繁透析经验显示出类似的改善，但是所有使用的传统高清机器均使用经过处理的市政供水，从而使患者经常暴露于促炎成分。我们使用NxStagetrade标记系统报告每周六次HD的儿科经验，该系统使用无菌透析液在家庭或中心环境中进行透析。四名患者（体重范围38-61.4 kg）完成了为期16周的研究。通过动态血压监测，患者的临时预处理收缩压和舒张压逐渐降低，停止使用降压药，降低血压负荷。平均血清磷改善，而磷结合剂用药不变，并且在研究开始时，每天标准化蛋白质分解代谢速率<1 g / kg的所有三名患者均改善至> 1.1 g / kg标准化蛋白质分解代谢率（nPCR）每天。患者未报告不良反应。观察到促炎细胞因子水平的变化。我们建议对于那些将从家庭维护性透析中受益的孩子，考虑使用带有NxStagetrade标记系统的频繁HD。

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