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首页> 外文期刊>Pediatric neurology >Disease-specific quality of life in young patients with Tourette syndrome
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Disease-specific quality of life in young patients with Tourette syndrome

机译：抽动秽语综合征年轻患者因疾病而异的生活质量

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Tourette syndrome is a neurodevelopmental disorder characterized by multiple tics and is often associated with comorbid behavioral problems. Research with generic instruments in child populations showed that comorbid disorders can have a greater impact on health-related quality of life than tic severity. This study investigated the usefulness of a newly developed disease-specific instrument, the Gilles de la Tourette Syndrome-Quality of Life Scale for Children and Adolescents (GTS-QOL-C&A), in assessing health-related quality of life in young patients with Tourette syndrome with and without behavioral comorbidity. We recruited 75 patients with Tourette syndrome (60 males; age 12.4 ± 3.2 years). All participants were evaluated by a neuropsychiatrist and completed a standardized psychometric battery, including the GTS-QOL-C&A, Child Depression Inventory, and Multidimensional Anxiety Scale for Children. Forty-two patients (56%) fulfilled diagnostic criteria for at least one comorbidity: obsessive-compulsive disorder (n = 25 patients [33.3%]); attention deficit/hyperactivity disorder (n = 6 patients [8%]); both (n = 11 patients [14.7%]). The GTS-QOL-C&A demonstrated usefulness in differentiating "pure" Tourette syndrome from Tourette syndrome "plus" behavioral problems with regard to health-related quality of life scores for the obsessive-compulsive subscale. In addition to focusing on core tic symptoms, the GTS-QOL-C&A showed sensitivity to the impact of behavioral comorbidities on health-related quality of life and can usefully complement existing nonspecific instruments.
机译：Tourette综合征是一种以多种抽动为特征的神经发育障碍，通常与合并症相关。在儿童人群中使用通用仪器进行的研究表明，合并症可能比抽搐严重程度对健康相关生活质量的影响更大。这项研究调查了一种新开发的针对疾病的仪器，即吉尔斯·德·图雷特综合症儿童和青少年生活质量量表（GTS-QOL-C＆A）在评估图雷特青年患者与健康相关的生活质量方面的实用性有或没有行为合并症的综合征。我们招募了75例Tourette综合征患者（60例男性; 12.4±3.2岁）。所有参与者均由神经精神科医生进行了评估，并完成了标准化的心理测验，包括GTS-QOL-C＆A，儿童抑郁量表和儿童多维焦虑量表。四十二名患者（56％）满足至少一种合并症的诊断标准：强迫症（n = 25名患者[33.3％]）;注意缺陷/多动障碍（n = 6例[8％]）;两者（n = 11例患者[14.7％]）。 GTS-QOL-C＆A证明了在强迫症分量表的健康相关生活质量评分方面，可以将“纯粹的”图雷特综合征与“图雷特综合征”加号”行为问题区分开来。除了关注核心抽动症状外，GTS-QOL-C＆A还显示出对行为合并症对健康相关的生活质量影响的敏感性，并且可以有效地补充现有的非特异性手段。

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