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首页> 外文期刊>Pediatric neurology >Limbic encephalitis in a child: An atypical presentation
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Limbic encephalitis in a child: An atypical presentation

机译：儿童肢体脑炎：非典型表现

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Background Limbic encephalitis is a rare disorder with a generally subacute onset evolving over days to weeks. Patients present with a variable combination of memory loss, seizures, and psychiatric disturbance, and it is not rare for patients to be initially misdiagnosed. Patient We describe a previously healthy 12-year-old boy who developed his first seizures at 8 years of age. He had a total of eight prolonged focal seizures, each followed by a month of behavioral changes and short-term memory loss. There was no family history of seizures or other neurological disorders, and he had an otherwise unremarkable neonatal and medical history. Results Magnetic resonance imaging during each episode of seizures showed alternating unilateral brain hemispheric involvement consistent with limbic encephalitis that was followed by resolution for a total of six times. Despite a negative laboratory evaluation for a large panel of paraneoplastic antibodies, the clinical scenario and exclusion of other possible disorders made recurrent limbic encephalitis the most likely diagnosis. Conclusion Limbic encephalitis is a rare disorder that is diagnosed primarily on the basis of clinical criteria and is often associated with the presence of a paraneoplastic antibody. However, lack of a positive paraneoplastic antibody in a patient with a triad of seizure, behavioral changes, and short-term memory loss does not exclude the diagnosis. The unique presentation in a seronegative patient may indicate an unrecognized antibody.
机译：背景边缘性脑炎是一种罕见的疾病，一般亚急性发作发展数日至数周。患者会出现记忆力减退，癫痫发作和精神病性疾病的各种变化，而且最初被误诊的情况并不罕见。病人我们描述了一个以前健康的12岁男孩，他在8岁时首次发作。他总共有八次长时间的局灶性癫痫发作，每次发作后都有一个月的行为改变和短期记忆丧失。没有癫痫发作或其他神经系统疾病的家族病史，而他的新生儿和病史也很少。结果在每次发作中的磁共振成像显示，交替发生的单侧脑半球受累与边缘性脑炎相符，随后共解决了六次。尽管实验室对大量副肿瘤抗体进行了阴性评估，但临床情况和其他可能疾病的排除使复发性边缘性脑炎成为最可能的诊断方法。结论边缘性脑炎是一种罕见疾病，主要根据临床标准诊断，通常与副肿瘤抗体的存在有关。但是，癫痫发作，行为改变和短期记忆丧失三联征的患者缺乏阳性的副肿瘤抗体不能排除诊断。血清阴性患者的独特表现可能表明存在无法识别的抗体。

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