Localized morphea: a rare adverse effect of valproic acid.

Ferzli GT; El Tal Ael K; Kibbi AG; Mikati MA

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Localized morphea: a rare adverse effect of valproic acid.

机译：局部性吗啡：丙戊酸的罕见不良反应。

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Morphea, a specific type of cutaneous sclerosis, is known in the pediatric age group, but not as an adverse effect to the antiepileptic valproic acid. We report a 14-year-old male patient with absence seizures who, after treatment with valproic acid, developed skin tightness on the fingers. A biopsy specimen revealed dermal sclerosis consistent with morphea. His symptoms resolved gradually after discontinuation of the medication. To our knowledge, this is the first patient reported to have an apparently valproic acid-induced localized morphea.

机译：在儿童年龄组中已知Morphea是一种特殊类型的皮肤硬化症，但对抗癫痫药丙戊酸没有不良影响。我们报告了一名14岁的男性失神发作患者，在使用丙戊酸治疗后，手指上的皮肤紧绷。活检标本显示真皮硬化与吗啡一致。停药后他的症状逐渐消失。据我们所知，这是第一例据报道具有丙戊酸诱导的局部性吗啡的患者。

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《Pediatric neurology》 |2003年第3期|共3页
作者
Ferzli GT; El Tal Ael K; Kibbi AG; Mikati MA;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Scleroderma; Localized; Valproic Acid; 丙戊酸;

机译：硬皮病;局部化;丙戊酸;丙戊酸;

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1. Localized morphea: a rare adverse effect of valproic acid. [J] . Ferzli GT, El Tal Ael K, Kibbi AG, Pediatric neurology . 2003,第3期

机译：局部性吗啡：丙戊酸的罕见不良反应。
2. Localized Morphea – a Rare but Significant Secondary Complication Following Breast Cancer Radiotherapy [J] . Thomas Herrmann, Claudia Günther, Peter Csere Strahlentherapie und Onkologie . 2009,第9期

机译：局限性Morphea –乳腺癌放疗后罕见但重要的继发并发症
3. Unilateral generalized morphea is a rare variant of localized scleroderma. [J] . Appelhans C, Breuckmann F, Gambichler T, European journal of medical research. . 2006,第4期

机译：单侧全身性吗啡是局限性硬皮病的罕见变体。
4. Using constrained information entropy to detect rare adverse drug reactions from medical forums [C] . Yi Zheng, Chaowang Lan, Hui Peng, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2016

机译：使用约束信息熵检测医学论坛中罕见的药物不良反应
5. Behavioral, neurochemical, and neuroimmune changes in NRF2 knockout mice following early postnatal exposure to valproic acid. [D] . Furnari, Melody A. 2013

机译：出生后早期接触丙戊酸后，NRF2基因敲除小鼠的行为，神经化学和神经免疫发生变化。
6. A rare association of localized scleroderma type morphea vitiligo autoimmune hypothyroidism pneumonitis autoimmune thrombocytopenic purpura and central nervous system vasculitis. Case report [O] . Fabio Bonilla-Abadía, Evelyn Muñoz-Buitrón, Carlos D Ochoa, 2012

机译：罕见的局部硬皮病性吗啡白癜风自身免疫性甲状腺功能减退肺炎自身免疫性血小板减少性紫癜和中枢神经系统血管炎的关联。案例报告
7. Generalized morphea: A rare variant of localized scleroderma [O] . Sham S, Rajeswari S 2014

机译：广义的语气：局部硬皮病的罕见变体

Localized morphea: a rare adverse effect of valproic acid.

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