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首页> 外文期刊>Pediatric neurology >Prednisone therapy in pediatric epilepsy.
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Prednisone therapy in pediatric epilepsy.

机译：泼尼松治疗在小儿癫痫中的作用。

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Steroids are often an effective treatment for the West's syndrome. There have been few reports of steroid use in children with epilepsy outside the first year of life. I report my experience with prednisone for the treatment of older children with intractable epilepsy. Twenty-eight children (17 boys, 11 girls) aged 18 months to 10 years with intractable epilepsy were studied. Prednisone 1 mg/kg/day for 12 weeks (6 weeks daily and 6 weeks alternate therapy) was prescribed in addition to their regular antiepileptic medications. The parents kept seizure diaries, and the patients were regularly assessed for seizure frequency and side effects. The follow-up period was for 1 to 5 years. Thirteen patients (46%) became seizure free on prednisone and another 18 (40%) had a significant decrease in seizure frequency. Five patients (19%) had no change in seizure frequency. The best outcomes were seen in the absence group in which six out of seven patients became seizure free and in the Lennox-Gastaut syndrome group in which seven out of 10 became seizure free. Side effects were uncommon and included weight gain in five patients and aggression in four patients. Prednisone therapy is a safe and effective adjunctive treatment for epilepsy. It should be considered as an alternative treatment for older children with intractable generalized epilepsy who have failed conventional antiepileptic therapy.
机译：类固醇通常是治疗西方综合症的有效方法。在生命的第一年之后，对于癫痫患儿使用类固醇的报道很少。我报告了泼尼松治疗顽固性癫痫的年龄较大的儿童的经验。研究对象为28例年龄18个月至10岁的顽固性癫痫患儿（男17例，女11例）。除常规抗癫痫药物外，还开具泼尼松1 mg / kg /天，持续12周（每天6周，交替治疗6周）。父母保留癫痫发作日记，并定期评估患者的癫痫发作频率和副作用。随访期为1至5年。 13名患者（46％）接受泼尼松免于癫痫发作，另有18名（40％）的癫痫发作频率显着降低。五名患者（19％）的癫痫发作频率无变化。在失神组中，七分之六的患者无癫痫发作;在伦诺克斯-加索特综合症组中，十分之七的患者无癫痫发作，结果最好。副作用不常见，包括五名患者体重增加和四名患者攻击性。泼尼松治疗是癫痫的一种安全有效的辅助治疗。对于传统抗癫痫治疗失败的顽固性全身性癫痫大龄儿童，应考虑将其作为替代治疗。

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