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首页> 外文期刊>Pediatric neurology >Amplitude Electroencephalogram Characterization in Preterm Infants Undergoing Patent Ductus Arteriosus Ligation
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Amplitude Electroencephalogram Characterization in Preterm Infants Undergoing Patent Ductus Arteriosus Ligation

机译：动脉导管未闭结的早产儿的振幅脑电图表征

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BACKGROUND: Recent studies suggest an increased risk of neurodevelopmental impairment following patent ductus arteriosus surgical ligation. The mechanisms are unclear, but intraoperative stress or pain may contribute. The objectives of this study were to determine if pain, evidenced by an increase in heart rate and blood pressure, during patent ductus arteriosus ligation would be accompanied by an increase in amplitude-integrated electroencephalogram (aEEG) voltage. METHODS: This was an observational, pilot study of infants born at 22.6-35.1 weeks with patent ductus arteriosus requiring surgical ligation. The aEEG was recorded prior to, during surgery, and for 2 hours following surgery. Mean heart rate, blood pressure, and aEEG voltage were analyzed for each recording period. RESULTS: Seventeen preterm infants were studied at a mean postmenstrual age of 26.6 weeks. Following anesthetic induction, aEEG became suppressed and remained suppressed during the postoperative period. Heart rate and blood pressure increased significantly intraoperatively. The aEEG voltage did not increase with an increase in heart rate. Infants received between 3.7-47 mu g/kg of fentanyl. CONCLUSIONS: There was no correlation between aEEG voltage and vital sign changes. aEEG is not a useful tool as a marker of pain during patent ductus arteriosus ligation, rather a more standardized approach to pain management should be considered. (C) 2013 Elsevier Inc. All rights reserved.
机译：背景：最近的研究表明动脉导管未闭手术结扎后神经发育受损的风险增加。机制尚不清楚，但是术中的压力或疼痛可能是造成这种情况的原因。这项研究的目的是确定在动脉导管未闭结扎期间由心率和血压升高证明的疼痛是否会伴随振幅积分脑电图（aEEG）电压的升高。方法：这是一项观察性，初步研究，研究对象是22.6-35.1周出生的动脉导管未闭需要手术结扎的婴儿。术前，术中和术后2小时记录aEEG。在每个记录期间分析平均心率，血压和aEEG电压。结果：研究了17名早产儿，平均月经后年龄为26.6周。麻醉诱导后，aEEG被抑制并在术后期间保持抑制状态。术中心率和血压明显升高。 aEEG电压并未随心率的增加而增加。婴儿接受的芬太尼为3.7-47微克/千克。结论：aEEG电压和生命体征变化之间没有相关性。 aEEG并不是动脉导管未闭结扎时疼痛的有用工具，而应考虑采用更为标准化的疼痛处理方法。 （C）2013 Elsevier Inc.保留所有权利。

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