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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Infant sleep after immunization: randomized controlled trial of prophylactic acetaminophen.
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Infant sleep after immunization: randomized controlled trial of prophylactic acetaminophen.

机译：免疫后的婴儿睡眠：预防性对乙酰氨基酚的随机对照试验。

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OBJECTIVE: To determine the effects of acetaminophen and axillary temperature responses on infant sleep duration after immunization. METHODS: We conducted a prospective, randomized controlled trial to compare the sleep of 70 infants monitored by using ankle actigraphy for 24 hours before and after their first immunization series at approximately 2 months of age. Mothers of infants in the control group received standard care instructions from their infants' health care provider, and mothers of infants in the intervention group were provided with predosed acetaminophen and instructed to administer a dose 30 minutes before the scheduled immunization and every 4 hours thereafter, for a total of 5 doses. Infant age and birth weight and immunization factors, such as acetaminophen use and timing of administration, were evaluated for changes in infant sleep times after immunization. RESULTS: Sleep duration in the first 24 hours after immunization was increased, particularly for infants who received their immunizations after 1:30 pm and for those who experienced elevated temperatures in response to the vaccines. Infants who received acetaminophen at or after immunization had smaller increases in sleep duration than did infants who did not. However, acetaminophen use was not a significant predictor of sleep duration when other factors were controlled. CONCLUSIONS: If further research confirms the relationship between time of day of vaccine administration, increased sleep duration after immunization, and antibody responses, then our findings suggest that afternoon immunizations should be recommended to facilitate increased sleep in the 24 hours after immunization, regardless of acetaminophen administration.
机译：目的：确定对乙酰氨基酚和腋窝温度反应对免疫后婴儿睡眠时间的影响。方法：我们进行了一项前瞻性，随机对照试验，比较了70名婴儿在大约2个月大的首次免疫系列前后前后24小时使用脚踝肌电描记法监测的睡眠。对照组的婴儿母亲从其婴儿的医疗保健提供者那里接受了标准的护理说明，干预组的婴儿母亲接受了预先接种的对乙酰氨基酚，并被要求在计划免疫前30分钟和之后每4小时给予一次剂量，总共5剂。评估了婴儿的年龄和出生体重以及免疫因素，例如对乙酰氨基酚的使用和给药时间，以了解免疫后婴儿睡眠时间的变化。结果：免疫后头24小时的睡眠时间增加了，特别是对于在下午1:30以后接受免疫的婴儿以及那些对疫苗反应温度升高的婴儿。与未接受对乙酰氨基酚的婴儿相比，接受免疫对乙酰氨基酚的婴儿的睡眠时间增加幅度较小。但是，当控制其他因素时，对乙酰氨基酚的使用并不是睡眠时间的重要预测指标。结论：如果进一步的研究证实了疫苗接种当天的时间，免疫后增加的睡眠时间和抗体反应之间的关系，那么我们的发现表明，无论对乙酰氨基酚如何，均应建议进行下午免疫以促进免疫后24小时的增加睡眠行政。

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