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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Functional abdominal pain in childhood and long-term vulnerability to anxiety disorders
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Functional abdominal pain in childhood and long-term vulnerability to anxiety disorders

机译：儿童期功能性腹痛和长期易患焦虑症

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BACKGROUND: Cross-sectional studies link functional abdominal pain (FAP) to anxiety and depression in childhood, but no prospective study has evaluated psychiatric status in adulthood or its relation to pain persistence. METHODS: Pediatric patients with FAP (n = 332) and control subjects (n = 147) were tracked prospectively and evaluated for psychiatric disorders and functional gastrointestinal disorders (FGIDs) at followup in adolescence and young adulthood (mean age = 20.01 years). Participants were classified according to presence (FGID-POS) or absence (FGID-NEG) of FGIDs at follow-up. RESULTS: Lifetime and current risk of anxiety disorders was higher in FAP than controls (lifetime: 51% vs 20%; current: 30% vs 12%). Controlling for gender and age, the odds ratio was 4.9 (confidence interval = 2.83-7.43) for lifetime anxiety disorder and 3.57 (confidence interval = 2.00-6.36) for current anxiety disorder at follow-up for FAP versus controls. Lifetime risk of depressive disorder was significantly higher in FAP versus controls (40% vs. 16%); current risk did not differ. In most cases, initial onset of anxiety disorders was before pediatric FAP evaluation; onset of depressive disorders was subsequent to FAP evaluation. Within the FAP group, risk of current anxiety disorders at follow-up was significantly higher for FGID-POS versus FGID-NEG (40% vs 24%), and both were higher than controls (12%); current depressive disorders did not differ across FGID-POS, FGID-NEG, and controls. CONCLUSIONS: Patients with FAP carry long-term vulnerability to anxiety that begins in childhood and persists into late adolescence and early adulthood, even if abdominal pain resolves.
机译：背景：横断面研究将功能性腹痛（FAP）与儿童时期的焦虑和抑郁联系在一起，但尚无前瞻性研究评估成年后的精神状态或与疼痛持续性的关系。方法：对FAP（n = 332）和对照组（n = 147）的儿童患者进行前瞻性跟踪，并在青春期和成年青年（平均年龄20.01岁）的随访中评估其精神疾病和功能性胃肠道疾病（FGID）。随访时根据FGID的存在（FGID-POS）或不存在（FGID-NEG）对参与者进行分类。结果：FAP的终生和当前焦虑症风险高于对照组（终生：51％vs 20％;当前：30％vs 12％）。在控制性别和年龄方面，FAP与对照组相比，终生焦虑症的优势比为4.9（置信区间= 2.83-7.43），当前焦虑症的优势比为3.57（信心区间= 2.00-6.36）。与对照相比，FAP的终生抑郁症风险显着更高（40％vs. 16％）;目前的风险没有不同。在大多数情况下，焦虑症的初始发作是在儿科FAP评估之前。 FAP评估后开始抑郁症的发作。在FAP组中，FGID-POS相对于FGID-NEG随访时当前焦虑症的风险显着更高（40％比24％），并且均高于对照组（12％）。当前的抑郁症在FGID-POS，FGID-NEG和对照组之间没有差异。结论：患有FAP的患者长期存在对焦虑的脆弱性，这种焦虑始于儿童期，即使腹痛缓解，也持续到青春期晚期和成年早期。

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