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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Successful IVIG Treatment of Human Parechovirus-Associated Dilated Cardiomyopathy in an Infant
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Successful IVIG Treatment of Human Parechovirus-Associated Dilated Cardiomyopathy in an Infant

机译：IVIG成功治疗婴儿与人类细支病毒相关的扩张型心肌病

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Human parechoviruses (HPeVs) are closely related to human enteroviruses and exhibit many similarities in disease spectrum and symptoms. HPeV1 is most commonly associated with mild disease, but rare associations with severe disease such as myocarditis have been reported. Currently, no treatment is available for severe HPeV infections. In this case report we describe an infant with a severe, dilated cardiomyopathy in whom HPeV1 was revealed to be the only identifiable cause. The infant was treated with intravenous immunoglobulins (IVIGs) and recovered completely. In vivo blood samples revealed a high HPeV1 antibody titer after treatment with IVIGs. In vitro IVIGs contained high titers of neutralizing antibodies against HPeV1. Our hypothesis is that patients with myocarditis caused by viruses with a high prevalence in the population and hence high antibody titers in IVIGs are likely to benefit from treatment with IVIGs. More research combining virological and clinical data is needed to see whether this hypothesis is true.
机译：人副病毒（HPeV）与人肠病毒密切相关，并且在疾病谱和症状上表现出许多相似之处。 HPeV1最常与轻度疾病相关，但已报道与严重疾病（如心肌炎）的罕见关联。当前，没有针对严重HPeV感染的治疗方法。在此病例报告中，我们描述了患有严重扩张型心肌病的婴儿，其中HPeV1被发现是唯一可确定的原因。该婴儿接受了静脉免疫球蛋白（IVIG）治疗，并完全康复。用IVIG治疗后，体内血液样本显示出高HPeV1抗体滴度。体外IVIG含有高滴度的针对HPeV1的中和抗体。我们的假设是，由人群中高患病率的病毒引起的心肌炎患者可能因此从IVIG治疗中受益。需要进行结合病毒学和临床数据的更多研究，以了解这一假设是否正确。

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