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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Nebulized hypertonic saline without adjunctive bronchodilators for children with bronchiolitis.
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Nebulized hypertonic saline without adjunctive bronchodilators for children with bronchiolitis.

机译：细支气管炎患儿的雾化高渗盐水，无辅助支气管扩张剂。

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OBJECTIVE: The goal was to determine an adverse event rate for nebulized hypertonic saline solution administered without adjunctive bronchodilators for infants with bronchiolitis. METHODS: This was a retrospective cohort study of the use of nebulized 3% saline for children<2 years of age who were hospitalized with the primary diagnosis of bronchiolitis at a single academic medical center. The medical records of study participants were analyzed for the use of nebulized 3% saline solution and any documented adverse events related to this therapy. Other clinical outcomes evaluated included respiratory distress scores, timing of the use of bronchodilators in relation to 3% saline solution, transfer to a higher level of care, and readmission within 72 hours after discharge. RESULTS: A total of 444 total doses of 3% saline solution were administered, with 377 doses (85%) being administered without adjunctive bronchodilators. Four adverse events occurred with these 377 doses, for a 1.0% adverse event rate (95% confidence interval: 0.3%-2.8%). Adverse events were generally mild. One episode of bronchospasm was documented, for a rate of 0.3% (95% confidence interval: <0.01%-1.6%). CONCLUSIONS: The use of 3% saline solution without adjunctive bronchodilators for inpatients with bronchiolitis had a low rate of adverse events in our center. Additional clinical trials of 3% saline solution in bronchiolitis should evaluate its effectiveness in the absence of adjunctive bronchodilators.
机译：目的：确定毛细支气管炎婴儿不加辅助支气管扩张剂的雾化高渗盐溶液的不良事件发生率。方法：这是一项回顾性队列研究，研究对象是在单个学术医疗中心对2岁以下因细支气管炎进行初步诊断而住院的2岁以下儿童使用雾化的3％盐水。分析研究参与者的病历，了解是否使用了雾化的3％盐溶液以及任何与该疗法有关的不良事件。评估的其他临床结局包括呼吸窘迫评分，相对于3％盐溶液使用支气管扩张药的时间，转移至更高水平的护理以及出院后72小时内再次入院。结果：总共服用444剂3％盐溶液，其中377剂（85％）不使用辅助性支气管扩张剂。这些377剂药物发生了4次不良事件，不良事件发生率为1.0％（95％置信区间：0.3％-2.8％）。不良事件一般较轻。记录到一例支气管痉挛，发生率为0.3％（95％置信区间：<0.01％-1.6％）。结论：在我院，细支气管炎住院患者使用不加辅助支气管扩张剂的3％盐溶液的不良事件发生率较低。在细支气管炎中使用3％盐溶液的其他临床试验应评估在不存在辅助性支气管扩张剂的情况下的有效性。

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