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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Retinol status of newborn infants is associated with congenital diaphragmatic hernia.
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Retinol status of newborn infants is associated with congenital diaphragmatic hernia.

机译：新生儿的视黄醇状态与先天性diaphragm肌疝有关。

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OBJECTIVE: Genetic analyses in humans suggest a role for retinoid-related genes in the pathogenesis of congenital diaphragmatic hernia (CDH). The goal of this study was to investigate the vitamin A status of mothers and their newborns in association with CDH. METHODS: We conducted a hospital-based, case-control study with 22 case and 34 control mothers and their newborns. In maternal and cord blood samples, retinol and retinol-binding protein (RBP) levels were measured with high-performance liquid chromatography and an enzyme-linked immunosorbent assay, respectively. Univariate and multivariate logistic regression analyses were performed to determine crude and adjusted risk estimates. RESULTS: Case newborns had significantly lower levels of retinol (0.60 vs 0.76 mumol/L; P=.003) and RBP (5.42 vs 7.11 mg/L; P=.02) than did control newborns. The multivariate logistic regression analysis showed lower levels of retinol and RBP in association with CDH risk; the odds ratio for retinol levels of <15th percentile (<0.61 mumol/L) was 11.11 (95% confidence interval: 2.54-48.66; P=.001), and that for RBP levels of <15th percentile (<4.54 mg/L) was 4.00 (95% confidence interval: 1.00-15.99; P=.05). Retinol and RBP levels were not different between case and control mothers. CONCLUSIONS: CDH is strongly associated with low retinol and RBP levels in newborns, independent of maternal retinol status. This is an important finding supporting the idea that human CDH is linked with abnormal retinoid homeostasis.
机译：目的：人类的遗传分析表明，类维生素A相关基因在先天性diaphragm肌疝（CDH）的发病机制中具有重要作用。这项研究的目的是调查与CDH相关的母亲及其新生儿的维生素A状况。方法：我们进行了一项基于医院的病例对照研究，对22例病例和34名对照母亲及其新生儿进行了研究。在母体和脐带血样品中，分别通过高效液相色谱和酶联免疫吸附测定法测定了视黄醇和视黄醇结合蛋白（RBP）的水平。进行了单因素和多元逻辑回归分析，以确定粗略和调整后的风险估计。结果：该病例新生儿的视黄醇水平（0.60 vs. 0.76 mumol / L; P = .003）和RBP（5.42 vs 7.11 mg / L; P = .02）显着低于对照组新生儿。多元logistic回归分析显示，视黄醇和RBP水平降低与CDH风险相关;视黄醇水平<15％（<0.61μmol/ L）的比值比为11.11（95％置信区间：2.54-48.66; P = .001），而RBP水平<15％（<4.54 mg / L） ）为4.00（95％置信区间：1.00-15.99; P = .05）。案例母亲和对照组母亲之间的视黄醇和RBP水平没有差异。结论：CDH与新生儿视黄醇和RBP水平低密切相关，与母亲视黄醇状态无关。这是一项重要发现，支持了人类CDH与异常类维生素A稳态相关的观点。

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