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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Early hyperglycemia is a risk factor for death and white matter reduction in preterm infants.
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Early hyperglycemia is a risk factor for death and white matter reduction in preterm infants.

机译：早期高血糖症是早产儿死亡和减少白质的危险因素。

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OBJECTIVE: The objective of this study was to determine whether hyperglycemia during the first week of life in extremely preterm (EPT) infants was associated with increased mortality rates and with cerebral injury, as assessed with MRI of the brain, at term-equivalent age. METHODS: All 143 EPT infants (gestational ages of <27 weeks) who were born at Karolinska University Hospital between January 2004 and December 2006 and were alive at 24 hours were eligible. Of the 118 surviving infants, 24 were excluded for various reasons. MRI was performed for the 94 included survivors at term age, with a 1.5-T system, and scans were scored for gray matter/white matter (WM) abnormalities. Of the 25 infants who died before term age, 6 were excluded because of missing glucose documentation and the remaining 19 were included. Hyperglycemia was defined as plasma glucose levels of >8.3 mmol/L. RESULTS: Hyperglycemia occurring on the first day of life was identified as an independent risk factor for death (adjusted odds ratio: 3.7 [95% confidence interval: 1.3-10.6]; P = .01). Hyperglycemia occurring on the first day of life also was a risk factor for WM reduction, as determined through MRI, at term-equivalent age (adjusted odds ratio: 3.1 [95% confidence interval: 1.0-9.2]; P = .04). CONCLUSION: In this population-based cohort of EPT infants, hyperglycemia on the first day of life was associated with increased mortality rates and brain damage, as reflected by WM reduction at term age.
机译：目的：本研究的目的是确定在极端早产（EPT）婴儿出生后第一周的高血糖症是否与足月等效年龄的脑部MRI死亡率升高和脑损伤有关。方法：2004年1月至2006年12月在卡罗林斯卡大学医院出生并在24小时存活的所有143例EPT婴儿（胎龄<27周）均符合条件。在118名存活的婴儿中，有24名由于各种原因被排除在外。对年龄在94岁的幸存幸存者使用1.5-T系统进行MRI检查，并对扫描的灰质/白质（WM）异常评分。在足月龄之前死亡的25例婴儿中，有6例由于缺少葡萄糖记录而被排除在外，其余19例也包括在内。高血糖定义为血浆葡萄糖水平> 8.3 mmol / L。结果：出生后第一天发生的高血糖被确定为死亡的独立危险因素（校正比值比：3.7 [95％置信区间：1.3-10.6]; P = 0.01）。通过MRI测定，足月等效年龄时，在出生的第一天发生的高血糖也是WM降低的危险因素（校正比值比：3.1 [95％置信区间：1.0-9.2]; P = .04）。结论：在这个以人群为基础的EPT婴儿队列中，出生后第一天的高血糖与死亡率和脑损伤增加有关，这在足月儿WM减少中可以看出。

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