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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >The association of acetaminophen and asthma prevalence and severity.
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The association of acetaminophen and asthma prevalence and severity.

机译：对乙酰氨基酚与哮喘患病率和严重程度的关系。

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摘要

The epidemiologic association between acetaminophen use and asthma prevalence and severity in children and adults is well established. A variety of observations suggest that acetaminophen use has contributed to the recent increase in asthma prevalence in children: (1) the strength of the association; (2) the consistency of the association across age, geography, and culture; (3) the dose-response relationship; (4) the timing of increased acetaminophen use and the asthma epidemic; (5) the relationship between per-capita sales of acetaminophen and asthma prevalence across countries; (6) the results of a double-blind trial of ibuprofen and acetaminophen for treatment of fever in asthmatic children; and (7) the biologically plausible mechanism of glutathione depletion in airway mucosa. Until future studies document the safety of this drug, children with asthma or at risk for asthma should avoid the use of acetaminophen.
机译：儿童和成人对乙酰氨基酚的使用与哮喘患病率和严重程度之间的流行病学关联已得到充分确立。各种观察结果表明，对乙酰氨基酚的使用已导致近期儿童哮喘患病率上升：（1）关联的强度; （2）跨年龄，地理和文化的关联的一致性; （3）剂量反应关系; （4）对乙酰氨基酚使用增加和哮喘流行的时机; （5）各国对乙酰氨基酚的人均销售额与哮喘患病率之间的关系; （6）布洛芬和对乙酰氨基酚治疗哮喘儿童发烧的双盲试验结果; （7）气道粘膜中谷胱甘肽耗竭的生物学机制。在进一步的研究证明该药的安全性之前，患有哮喘或有哮喘风险的儿童应避免使用对乙酰氨基酚。

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