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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Influenza-associated pediatric deaths in the united states, 2004-2012
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Influenza-associated pediatric deaths in the united states, 2004-2012

机译：2004-2012年美国与流感相关的儿科死亡

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BACKGROUND: Influenza-associated deaths in children occur annually. We describe the epidemiology of influenza-associated pediatric deaths from the 2004-2005 through the 2011-2012 influenza seasons. METHODS: Deaths in children ,18 years of age with laboratoryconfirmed influenza virus infection were reported to the Centers for Disease Control and Prevention by using a standard case report form to collect data on demographic characteristics, medical conditions, clinical course, and laboratory results. Characteristics of children with no high-risk medical conditions were compared with those of children with high-risk medical conditions. RESULTS: From October 2004 through September 2012, 830 pediatric influenza-associated deaths were reported. The median age was 7 years (interquartile range: 1-12 years). Thirty-five percent of children died before hospital admission. Of 794 children with a known medical history, 43% had no high-risk medical conditions, 33% had neurologic disorders, and 12% had genetic or chromosomal disorders. Children without high-risk medical conditions were more likely to die before hospital admission (relative risk: 1.9; 95% confidence interval: 1.6-2.4) and within 3 days of symptom onset (relative risk: 1.6; 95% confidence interval: 1.3-2.0) than those with high-risk medical conditions. CONCLUSIONS: Influenza can be fatal in children with and without highrisk medical conditions. These findings highlight the importance of recommendations that all children should receive annual influenza vaccination to prevent influenza, and children who are hospitalized, who have severe illness, or who are at high risk of complications (age ,2 years or with medical conditions) should receive antiviral treatment as early as possible. Pediatrics 2013;132:796-804.
机译：背景：与流感有关的儿童死亡每年发生。我们描述了从2004-2005年到2011-2012年流感季节与流感相关的小儿死亡的流行病学。方法：使用标准病例报告表向疾病控制和预防中心报告18岁实验室确诊的流感病毒感染儿童的死亡情况，以收集有关人口统计学特征，医疗状况，临床过程和实验室结果的数据。比较没有高危医疗条件的儿童的特征与有高危医疗条件的儿童的特征。结果：从2004年10月到2012年9月，报告了830例与小儿流感相关的死亡。中位年龄为7岁（四分位间距：1-12岁）。 35％的儿童在入院前死亡。在794名有已知病史的儿童中，有43％没有高危医疗条件，有33％有神经系统疾病，有12％有遗传或染色体疾病。没有高危医疗条件的儿童更有可能在入院前死亡（相对风险：1.9; 95％置信区间：1.6-2.4）和症状发作的三天内（相对风险：1.6; 95％置信区间：1.3- 2.0）高于高危医疗条件。结论：无论是否患有高危医疗状况，流感对儿童均可能致命。这些发现凸显了以下建议的重要性：建议所有儿童应每年接种流感疫苗以预防流感，住院，重病或有高并发症风险（2岁或患有疾病）的儿童也应接受此类接种尽早进行抗病毒治疗。儿科2013; 132：796-804。

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