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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Prevalence of congenital hypothyroidism--current trends and future directions: workshop summary.
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Prevalence of congenital hypothyroidism--current trends and future directions: workshop summary.

机译：先天性甲状腺功能减退的流行-当前趋势和未来方向：研讨会总结。

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摘要

In response to published newborn-screening data that have shown an increase in the incidence (birth prevalence) rate of primary congenital hypothyroidism (CH) in the United States, a workshop was held in Atlanta, Georgia, on February 27 and 28, 2008, to examine this issue. Topics of the meeting included pathophysiology, medical management, and follow-up of CH; transient hypothyroidism (etiology, clinical implications, management, and changes in prevalence); risk factors for CH; laboratory approaches to newborn screening for CH; state-specific evaluations of trends in incidence rates of CH; and concluding discussions on future directions to resolve outstanding issues. Through presentations and discussion, gaps in knowledge were identified, such as the lack of consistent definitions for CH and transient hypothyroidism and the effects of preventable risk factors on incidence rates of CH. One outcome of the meeting was a series of accompanying articles that examined (1) trends in the incidence rates of CH in individual states and nationally, (2) effects of newborn-screening practices on CH-incidence rates, (3) the contribution of transient hypothyroidism to CH-incidence rates, and (4) future research directions. In this summary, we briefly touch on the topics of these articles and examine highlights of other presentations from the workshop that illuminated the secular trends in reported CH-incidence rates in the United States.
机译：为了回应已公布的新生儿筛查数据显示美国原发性先天性甲状腺功能减退症（CH）的发病率（出生率）增加，2008年2月27日至28日在乔治亚州亚特兰大举行了一次研讨会，研究这个问题。会议的主题包括病理生理学，医疗管理和CH的随访。短暂性甲状腺功能减退症（病因，临床意义，管理和患病率变化）; CH的危险因素;新生儿CH筛查的实验室方法;对CH发生率趋势的州特定评估;最后讨论解决未决问题的未来方向。通过演讲和讨论，发现了知识方面的空白，例如缺乏一致的CH定义和短暂性甲状腺功能减退以及可预防的危险因素对CH发生率的影响。会议的一项成果是一系列附带的文章，这些文章审查了（1）各个州和全国CH发病率的趋势，（2）新生儿筛查实践对CH发病率的影响，（3）一过性甲状腺功能减退到CH发生率，以及（4）未来的研究方向。在此摘要中，我们简要介绍了这些文章的主题，并研究了研讨会上其他演讲的重点，这些演讲阐明了美国报告的CH发生率的长期趋势。

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