...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Noninvasive ventilation for respiratory distress syndrome: a randomized controlled trial.
【24h】

Noninvasive ventilation for respiratory distress syndrome: a randomized controlled trial.

机译：呼吸窘迫综合征的无创通气：一项随机对照试验。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CONTEXT: Strategies for reducing exposure to endotracheal ventilation through the use of early noninvasive ventilation has proven to be safe and effective, but the option with the greatest benefits needs to be determined. OBJECTIVE: To determine, in infants with respiratory distress syndrome, if early nasal intermittent positive-pressure ventilation (NIPPV) compared with nasal continuous positive airway pressure (NCPAP) decreases the need for mechanical ventilation. PATIENTS AND METHODS: In this single-center, randomized controlled trial, infants (gestational ages 26 to 33/7 weeks) with respiratory distress syndrome were randomly assigned to receive early NIPPV or NCPAP. Surfactant was administered as rescue therapy. The primary outcome was the need for mechanical ventilation within the first 72 hours of life. RESULTS: A total of 200 infants, 100 in each arm, were randomly assigned. Rates of the primary outcome did not differ significantly between the NIPPV (25%) and NCPAP (34%) groups (relative risk [RR]: 0.71 [95% confidence interval (CI): 0.48-1.14]). In posthoc analysis, from 24 to 72 hours of life, significantly more infants in the NIPPV group remained extubated compared with those in the NCPAP groups (10 vs 22%; RR: 0.45 [95% CI: 0.22-0.91]). This difference was also noted in the group of infants who received surfactant therapy, NIPPV (10.9%), and NCPAP (27.1%) (RR: 0.40 [95% CI: 0.18-0.86]). CONCLUSIONS: Early NIPPV did not decrease the need for mechanical ventilation compared with NCPAP, overall, in the first 72 hours of life. However, further studies to assess the potential benefits of noninvasive ventilation are warranted, especially for the most vulnerable or preterm infants.
机译：背景：通过使用早期的无创通气减少气管内通气的策略已被证明是安全有效的，但是需要确定具有最大益处的方案。目的：确定呼吸窘迫综合征婴儿早期鼻腔间歇性正压通气（NIPPV）与鼻腔持续气道正压通气（NCPAP）相比是否减少了机械通气的需要。患者与方法：在这项单中心，随机对照试验中，患有呼吸窘迫综合征的婴儿（胎龄26至33/7周）被随机分配为接受早期NIPPV或NCPAP。使用表面活性剂作为抢救疗法。主要结局是在生命的前72小时内需要机械通气。结果：总共200名婴儿被随机分配，每组100只。 NIPPV（25％）和NCPAP（34％）组之间的主要结局发生率无显着差异（相对风险[RR]：0.71 [95％置信区间（CI）：0.48-1.14]）。在事后分析中，从出生24小时到72小时，与NCPAP组相比，NIPPV组的拔管婴儿明显增加（10％vs 22％; RR：0.45 [95％CI：0.22-0.91]）。在接受表面活性剂治疗，NIPPV（10.9％）和NCPAP（27.1％）的婴儿组中也注意到了这种差异（RR：0.40 [95％CI：0.18-0.86]）。结论：与NCPAP相比，在生命的最初72小时内，早期NIPPV并未减少对机械通气的需求。但是，有必要进行进一步的研究来评估无创通气的潜在益处，尤其是对于最脆弱或早产儿。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号