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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Fasting Might Not Be Necessary Before Lipid Screening: A Nationally Representative Cross-sectional Study
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Fasting Might Not Be Necessary Before Lipid Screening: A Nationally Representative Cross-sectional Study

机译：筛查脂质前不必禁食：一项全国代表性的横断面研究

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BACKGROUND: There are barriers to fasting lipid screening for at-risk children. Results of studies in adults have suggested that lipid testing might be reliably performed without fasting. OBJECTIVE: To examine population-level differences in pediatric lipid values based on length of fast before testing. METHODS: We used the National Health and Nutrition Examination Survey (1999-2008) to examine total cholesterol (TO, HDL (high-density lipoprotein), LDL (low-density lipoprotein), and triglyceride cholesterol components on the basis of the period of fasting. Young children fasted for varying times before being tested, and children olderthan 12years were asked to fast; however, adherence was variable. We used ordinary least-squares regression to test for differences in lipid values that were based on fasting times, controlling for weight status, age, race, ethnicity, and gender. RESULTS: TC, HDL, LDL, or triglyceride values were available for 12 744 children. Forty-eight percent of the TC and HDL samples and 80% of the LDL and triglyceride samples were collected from children who had fasted >=8 hours. Fasting had a small positive effect for TC, HDL, and LDL, resulting in a mean value for the sample that was 2 to 5 mg/dL higher with a 12-hour fast compared with a no-fast sample. Fasting time had a negative effect on triglycerides (beta = -0.859; P = .02), which resulted in values in the fasting group that were 7 mg/dL lower. DISCUSSION: Comparison of cholesterol screening results for a non-fasting group of children compared with results for a similar fasting group resulted in small differences that are likely not clinically important. Physicians might be able to decrease the burden of childhood cholesterol screening by not requiring prescreening fasting for these components.
机译：背景：高危儿童禁食脂质筛查存在障碍。成年人的研究结果表明，可以在不禁食的情况下可靠地进行脂质测试。目的：根据测试前禁食的时间，检查儿童脂质值的人群水平差异。方法：我们使用美国国家健康与营养检查（1999-2008），根据总胆固醇的高低来检查总胆固醇（TO，HDL（高密度脂蛋白），LDL（低密度脂蛋白）和甘油三酸酯）胆固醇成分。禁食：幼儿在测试之前禁食不同时间，要求12岁以上的儿童禁食;但是，依从性是可变的，我们使用普通最小二乘回归来测试基于禁食时间的血脂值差异，控制结果：12 744名儿童可获得TC，HDL，LDL或甘油三酸酯值，其中TC和HDL样本占48％，LDL和甘油三酸酯样本占80％禁食> ​​= 8小时的儿童收集的食物，禁食对TC，HDL和LDL的积极影响较小，因此与12小时禁食相比，样品的平均值高2至5 mg / dL，禁食样品。 ime对甘油三酸酯有负面影响（beta = -0.859; P = .02），这导致空腹组的值降低了7 mg / dL。讨论：非空腹组儿童的胆固醇筛查结果与类似空腹组儿童的胆固醇筛查结果比较，导致很小的差异，可能对临床并不重要。通过不需要对这些成分进行空腹筛查，医生可以减轻儿童胆固醇筛查的负担。

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