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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Comparison of oral versus normal and high-dose rectal acetaminophen in the treatment of febrile children.
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Comparison of oral versus normal and high-dose rectal acetaminophen in the treatment of febrile children.

机译：口服，正常和大剂量对乙酰氨基酚治疗高热儿童的比较。

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摘要

OBJECTIVES: To compare the defervescent effect of high-dose rectal suppository acetaminophen with the recommended oral and rectal dosages and to evaluate acceptability of rectal acetaminophen. METHODS: A randomized, controlled trial was performed in 70 patients aged 6 months to 6 years with fever > or =39 degrees C. Group A received rectal acetaminophen 15 mg/kg, group B received rectal acetaminophen 30 mg/kg, and group C received oral acetaminophen 15 mg/kg. Primary outcome was maximal change in temperature during the 3-hour study period after initial treatment. RESULTS: There were 24 patients in group A, 23 in group B, and 23 in group C. There was no significant difference in temperature change between the groups during the 3 hours or in the maximum drop in temperature or final temperature. Visual analog scores for satisfaction of parents did not reveal any significant differences between the oral and rectal routes. CONCLUSIONS: There was no difference between the temperature decrement in patients treated with 15 mg/kg oral acetaminophen and the same or double dose rectally. Thus, there seems to be no evidence to support the use of higher doses of rectal acetaminophen for the treatment of fever in children. The rectal route proved to be as acceptable as the oral among parents.
机译：目的：比较大剂量直肠栓剂对乙酰氨基酚的退热作用与推荐的口服和直肠剂量，并评估直肠对乙酰氨基酚的可接受性。方法：对70例6个月至6岁且发烧≥39度的患者进行了一项随机对照试验。A组接受直肠对乙酰氨基酚15 mg / kg，B组接受直肠对乙酰氨基酚30 mg / kg，C组口服对乙酰氨基酚15 mg / kg。主要结果是初始治疗后3小时的研究期内温度的最大变化。结果：A组有24例患者，B组有23例，C组有23例。在3小时内，两组之间的温度变化或最大温度或最终温度下降无明显差异。视觉模拟评分对父母的满意度没有显示出口服和直肠途径之间的任何显着差异。结论：15 mg / kg口服对乙酰氨基酚治疗的患者与相同或两次剂量的直肠治疗的患者的体温下降没有差异。因此，似乎没有证据支持使用更高剂量的直肠对乙酰氨基酚治疗儿童发烧。直肠途径被证明与父母之间的口头治疗一样可以接受。

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