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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Lowered electroencephalographic spectral edge frequency predicts the presence of cerebral white matter injury in premature infants.
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Lowered electroencephalographic spectral edge frequency predicts the presence of cerebral white matter injury in premature infants.

机译：脑电图频谱边缘频率的降低预示了早产儿脑白质损伤的存在。

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OBJECTIVE: Current methods for early identification of cerebral white matter injury in the premature infant at the bedside are inadequate. This study investigated the utility of advanced spectral analysis of the neonatal electroencephalogram (EEG) in the early diagnosis of white matter injury in the premature infant. The critical measurement used, suggested largely by previous studies in animal models, was the spectral edge frequency (SEF), calculated here as the frequency below which 90% of the power in the EEG exists. METHODS: Fifty-nine very low birth weight infants (87% of eligible infants) had electrodes placed over the central and parietal regions (C3, P3, C4, and P4 sites according to the 10-20 international system) for the collection of EEG amplitude, intensity, and SEF. All averaged signals were analyzed off-line using software (Chart Analyzer; BrainZ Instruments, Auckland, NZ). All infants had a magnetic resonance imaging scan at term to identify the presence and severity of white matter injury. RESULTS: There was no significant difference between conventional EEG amplitude and intensity for infants with or without evidence of white matter injury. However, premature infants with increasingly severe white matter injury had progressively lower SEFs compared with infants who did not exhibit white matter injury. CONCLUSIONS: These data suggest that SEF-based measures are useful for defining the presence and severity of white matter injury at the bedside.
机译：目的：目前在床边早产儿早期识别脑白质损伤的方法尚不充分。这项研究调查了新生儿脑电图（EEG）的先进光谱分析在早产儿白质损伤的早期诊断中的实用性。先前在动物模型中的研究大都建议使用的关键测量是频谱边缘频率（SEF），在此计算为低于该频率时，EEG中存在90％的功率。方法：59名极低出生体重的婴儿（占合格婴儿的87％）在中部和顶叶区域（根据10-20国际系统的C3，P3，C4和P4部位）放置了电极，用于收集脑电图振幅，强度和SEF。使用软件（图表分析器; BrainZ Instruments，Auckland，NZ）对所有平均信号进行离线分析。所有婴儿在足月时都进行了磁共振成像扫描，以确定白质损伤的存在和严重程度。结果：无论有无白质损伤迹象的婴儿，常规脑电波振幅和强度之间均无显着差异。但是，与未表现出白质损伤的婴儿相比，患有越来越严重的白质损伤的早产儿的SEF逐渐降低。结论：这些数据表明基于SEF的措施可用于确定床旁白质损伤的存在和严重程度。

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