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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >The role of endogenous opioids in mediating pain reduction by orally administered glucose among newborns.
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The role of endogenous opioids in mediating pain reduction by orally administered glucose among newborns.

机译：内源性阿片类药物在新生儿口服葡萄糖介导的疼痛减轻中的作用。

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OBJECTIVE: It has been demonstrated clearly that sweet-tasting solutions given before a painful intervention can reduce pain among newborns. There is no fully accepted explanation for this effect, but activation of endogenous opioids has been suggested as a possible mechanism. The aim of this study was to obtain deeper knowledge of the underlying mechanism by investigating whether administration of an opioid antagonist would reduce the effect of orally administered glucose at heel stick among term newborns. DESIGN: A randomized, placebo-controlled, double-blind trial with a validated, neonatal, pain-rating scale. PARTICIPANTS: The trial included 30 term newborns undergoing heel stick, who were assigned randomly to 1 of 2 groups, ie, group I, with naloxone hydrochloride (opioid antagonist) 0.01 mg/kg administered intravenously before oral administration of 1 mL of 30% glucose, or group II, with a corresponding amount of placebo (saline solution) administered intravenously before oral administration of glucose. OUTCOME MEASURES: Pain-related behavior during blood sampling was measured with the Premature Infants Pain Profile. Crying time and heart rate were also recorded. RESULTS: The 2 groups did not differ significantly in Premature Infant Pain Profile scores during heel stick. The median crying time during the first 3 minutes was 14 seconds (range: 0-174 seconds) for the naloxone group and 105 seconds (range: 0-175 seconds) for the placebo group. There was no significant difference in heart rate between the 2 groups. CONCLUSION: Administration of an opioid antagonist did not decrease the analgesic effect of orally administered glucose given before blood sampling.
机译：目的：已经清楚地证明，在进行痛苦的干预之前给予甜味解决方案可以减轻新生儿的痛苦。对于这种作用尚没有完全被接受的解释，但是已提出内源性阿片样物质的激活是一种可能的机制。这项研究的目的是通过调查足月新生儿中阿片类药物拮抗剂的使用是否会降低口服葡萄糖在足跟贴上的作用，从而深入了解其潜在机制。设计：一项随机，安慰剂对照，双盲试验，具有经过验证的新生儿疼痛评定量表。参与者：该试验包括30例足跟贴足月新生儿，将其随机分为2组（即I组）中的1组，分别口服纳洛酮盐酸盐（阿片类药物拮抗剂）0.01 mg / kg，然后口服1 mL 30％葡萄糖或II组，在口服葡萄糖之前先静脉注射相应量的安慰剂（盐溶液）。观察指标：采用早产儿疼痛特征曲线测量血液采样过程中的疼痛相关行为。还记录了哭泣时间和心率。结果：两组在足跟贴期间的早产儿疼痛特征评分没有显着差异。纳洛酮组在最初3分钟内的中位哭泣时间为14秒（范围：0-174秒），安慰剂组为105秒（范围：0-175秒）。两组之间的心率无明显差异。结论：阿片类药物拮抗剂的给药不会降低在采血前口服葡萄糖的镇痛作用。

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