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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >The role of immunoprophylaxis in the reduction of disease attributable to respiratory syncytial virus.
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The role of immunoprophylaxis in the reduction of disease attributable to respiratory syncytial virus.

机译：免疫预防在减少可归因于呼吸道合胞病毒的疾病中的作用。

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摘要

Respiratory syncytial virus (RSV) is an RNA virus that infects human respiratory epithelial cells and causes annual outbreaks of respiratory tract disease among infants and young children, as well as recurrent infections throughout life. Annual outbreaks of RSV disease are attributable to first-time infection in susceptible infants, reinfection in children and adults with waning or incomplete immunity, and infection by viral genotypes with sufficient antigenic variation to avoid innate and acquired immunity. In industrialized countries, few infectious diseases have a greater effect on the health of young children than does lower respiratory tract disease caused by RSV. By 2 years of age, almost all children will experience an RSV infection, and~50% will be infected twice.
机译：呼吸道合胞病毒（RSV）是一种RNA病毒，可感染人的呼吸道上皮细胞，并导致婴幼儿每年爆发呼吸道疾病，并在一生中反复感染。 RSV疾病的年度暴发可归因于易感婴儿的首次感染，免疫力减弱或不完全的儿童和成人的再感染以及具有足够抗原性变异的病毒基因型感染，以避免先天和后天免疫。在工业化国家，很少有传染病比由RSV引起的下呼吸道疾病对幼儿的健康影响更大。到2岁时，几乎所有儿童都会受到RSV感染，约50％的儿童将被感染两次。

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