...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >A randomized, controlled trial comparing two different continuous positive airway pressure systems for the successful extubation of extremely low birth weight infants.
【24h】

A randomized, controlled trial comparing two different continuous positive airway pressure systems for the successful extubation of extremely low birth weight infants.

机译：一项随机对照试验，比较了两种不同的连续气道正压通气系统对极低出生体重婴儿的成功拔管。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To determine whether the use of the Infant Flow continuous positive airway pressure (IF CPAP) system reduces the rate of extubation failure among extremely low birth weight (ELBW) infants (infants with birth weight <1000 g) when compared with conventional CPAP delivered with a conventional ventilator and nasal prongs. METHODS: A prospective, unmasked, randomized, controlled clinical trial was conducted in 162 eligible intubated ELBW infants who were hospitalized in 2 intensive care nurseries in Winston-Salem, North Carolina, between July 1997 and November 2000. Successful extubation was defined as no need for reintubation for any reason for at least 7 days after the first extubation attempt. RESULTS: The individual extubation success rates were 61.9% (52 of 84) in the conventional CPAP group and 61.5% (48 of 78) in the IF CPAP group. There were no significant differences in the extubation success rate in any birth weight subset between the 2 cohorts. The most common cause of extubation failure was apnea/bradycardia. Infants who were randomized to IF CPAP had fewer days on supplemental O(2) and shorter hospital stays. CONCLUSIONS: Extubation failure is a common problem, occurring in nearly 40% of ELBW infants who require mechanical ventilation. IF CPAP was as effective but no more effective than conventional CPAP in preventing extubation failure among ELBW infants. New strategies are needed to identify predictors of extubation success and to treat apnea/bradycardia, the most common cause of extubation failure, thereby reducing the likelihood of prolonged intubation in this high-risk cohort of premature infants.
机译：目的：确定与常规CPAP相比，使用婴儿流持续气道正压通气（IF CPAP）系统是否可以降低极低出生体重（ELBW）婴儿（出生体重<1000 g的婴儿）的拔管失败率使用传统的呼吸机和鼻叉。方法：对1997年7月至2000年11月在北卡罗来纳州温斯顿-塞勒姆的2个重症监护托儿所住院的162例符合条件的插管ELBW婴儿进行了一项前瞻性，无掩盖性，随机对照临床研究。第一次拔管后至少7天出于任何原因重新插管。结果：常规CPAP组个体拔管成功率为61.9％（84例中的52例），IF CPAP组个体拔管成功率为61.5％（78例中的48例）。在这两个队列之间的任何出生体重子集中，拔管成功率均无显着差异。拔管失败的最常见原因是呼吸暂停/心动过缓。随机接受IF CPAP的婴儿补充O（2）的天数更少，住院时间更短。结论：拔管失败是一个普遍的问题，在将近40％的需要机械通气的ELBW婴儿中发生。 IF CPAP在预防ELBW婴儿拔管失败方面与传统CPAP一样有效，但效果不如传统CPAP。需要新的策略来确定拔管成功的预测因素并治疗呼吸暂停/心动过缓，这是拔管失败的最常见原因，从而降低了在这一高危早产儿中长时间插管的可能性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号