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首页> 外文期刊>Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies >Fomepizole alone for severe infant ethylene glycol poisoning.
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Fomepizole alone for severe infant ethylene glycol poisoning.

机译：单独使用甲吡咪唑治疗严重的婴儿乙二醇中毒。

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OBJECTIVE: To report a case of a massive ingestion of ethylene glycol in an infant successfully treated by fomepizole without hemodialysis. DESIGN: Descriptive case report. SETTING: Pediatric intensive care unit. Patient: A 5-mo-old boy who ingested 200 mL of an antifreeze solution. INTERVENTIONS: Antidotal therapy with a total of seven doses of fomepizole administered intravenously with an interval of 12 hrs (15 mg/kg as loading dose, then 10 mg/kg). Hemodialysis was not performed. MEASUREMENTS AND MAIN RESULTS: Iterative determination of ethylene glycol concentration was obtained in blood and urine. Kinetics were calculated for ethylene glycol and fomepizole elimination. The infant made a complete recovery with no change in renal function. CONCLUSIONS: Although not yet approved for this indication in the child, fomepizole seemed safe and effective in a case of severe ethylene glycol poisoning, without the need for hemodialysis.
机译：目的：报道一例在未接受血液透析的情况下经甲氧咪唑成功治疗的婴儿大量摄入乙二醇的病例。设计：描述性病例报告。地点：儿科重症监护室。病人：一个5个月大的男孩，他摄取了200毫升的防冻液。干预：总共7剂量的fomepizole的解毒疗法，间隔12小时（以15 mg / kg的负荷剂量，然后是10 mg / kg）静脉注射。没有进行血液透析。测量和主要结果：反复测定血液和尿液中的乙二醇浓度。计算了乙二醇和甲吡咪唑消除的动力学。婴儿完全康复，肾功能未改变。结论：尽管尚未批准在儿童中使用该药，但在严重的乙二醇中毒情况下，甲吡咪唑似乎安全有效，无需进行血液透析。

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