Bolus methylprednisolone efficacy for uncontrolled exacerbation of cystic fibrosis in children.

Ghdifan S; Couderc L; Michelet I; Leguillon C; Masseline B; Marguet C

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Bolus methylprednisolone efficacy for uncontrolled exacerbation of cystic fibrosis in children.

机译：丸甲基泼尼松龙对儿童囊性纤维化无节制恶化的疗效。

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We present here the clinical course of 4 children with cystic fibrosis, deltaF508/deltaF508, who were admitted with severe respiratory distress and in whom no improvement was obtained by intensive antibiotic therapy and systemic corticosteroids. Chest computed-tomography scans showed hyperinflation and atelectasis. The severity of these exacerbations was explained neither by visible mucus plugging nor by allergic bronchopulmonary aspergillosis. We hypothesized that these clinical features were related to a severe inflammatory process in small airways. Therefore, a high-dose short course of methylprednisolone (1 g/1.73 m(2) per day for 3 days) was given; all the patients' conditions were dramatically improved, and the therapy was safe. To our knowledge, this is the first reported use of bolus methylprednisolone in the treatment of uncontrolled pulmonary exacerbation in children with cystic fibrosis.

机译：我们在这里介绍了4名患有囊性纤维化的儿童delFF508 / deltaF508的临床历程，这些儿童因严重的呼吸窘迫而入院，而强化抗生素治疗和全身性皮质类固醇激素治疗并没有改善病情。胸部计算机断层扫描显示恶性通气和肺不张。这些恶化的严重程度既不能通过可见的粘液堵塞也不能通过过敏性支气管肺曲霉病来解释。我们假设这些临床特征与小气道中的严重炎症过程有关。因此，给予了大剂量的甲基强的松龙短期疗程（每天1 g / 1.73 m（2），共3天）;所有患者的病情都得到了明显改善，而且治疗是安全的。据我们所知，这是首次报道使用甲基强的松龙药丸治疗患有囊性纤维化的儿童不受控制的肺部急性加重。

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《Pediatrics: Official Publication of the American Academy of Pediatrics》 |2010年第5期|共6页
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Ghdifan S; Couderc L; Michelet I; Leguillon C; Masseline B; Marguet C;
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1. Bolus methylprednisolone efficacy for uncontrolled exacerbation of cystic fibrosis in children. [J] . Ghdifan S, Couderc L, Michelet I, Pediatrics: Official Publication of the American Academy of Pediatrics . 2010,第5期

机译：丸甲基泼尼松龙对儿童囊性纤维化无节制恶化的疗效。
2. Safety and tolerability of bolus intravenous colistin in acute respiratory exacerbations in adults with cystic fibrosis. [J] . Conway SP, Etherington C, Munday J, The annals of pharmacotherapy . 2000,第11期

机译：成人囊性纤维化急性加重期静脉推注粘菌素的安全性和耐受性。
3. Continuous infusion of ceftazidime with a portable pump is as effective as thrice-a-day bolus in cystic fibrosis children. [J] . Rappaz I, Decosterd LA, Bille J, European journal of pediatrics . 2000,第12期

机译：在囊性纤维化患儿中，用便携式泵连续注射头孢他啶与一日三次推注一样有效。
4. Assessment of serum mineral levels in cystic fibrosis children. I. Zinc, copper and iron [C] . Wojciak, R.W., Krejpcio, Workshop on Macro, Trace and Ultratrace Elements; 20040924-25; Jena(DE) . 2004

机译：评估囊性纤维化儿童的血清矿物质水平。 I.锌，铜和铁
5. Evaluation of Methods for the Statistical Analysis of Exacerbations in Cystic Fibrosis [D] . Dai, Xinyun. 2020

机译：囊性纤维化统计分析方法评价
6. The Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC) trial: Rationale and design of a multi-center double-blind placebo-controlled trial of high dose bolus administration of vitamin D3 during acute pulmonary exacerbation of cystic fibrosis [O] . Vin Tangpricha, Ellen M. Smith, Jose Binongo, 2017

机译：维生素D用于增强囊性纤维化（DISC）免疫系统的试验：多中心双盲安慰剂对照试验的原理和设计该试验在囊性纤维化的急性肺急性发作期间大剂量推注维生素D3
7. The Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC) trial: Rationale and design of a multi-center, double-blind, placebo-controlled trial of high dose bolus administration of vitamin D3 during acute pulmonary exacerbation of cystic fibrosis [O] . Vin Tangpricha, Ellen M. Smith, Jose Binongo, 2017

机译：用于增强囊性纤维化（DIsC）试验中免疫系统的维生素D：在囊性纤维化急性肺动脉加重期间高剂量推注维生素D3的多中心，双盲，安慰剂对照试验的基本原理和设计

Bolus methylprednisolone efficacy for uncontrolled exacerbation of cystic fibrosis in children.

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