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首页> 外文期刊>Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies >Prospective longitudinal evaluation of lung function during the first year of life after extracorporeal membrane oxygenation
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Prospective longitudinal evaluation of lung function during the first year of life after extracorporeal membrane oxygenation

机译：体外膜氧合后生命的第一年对肺功能的前瞻性纵向评估

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Objective: To collect longitudinal data on lung function in the first year of life after extracorporeal membrane oxygenation and to evaluate relationships between lung function and perinatal factors. Longitudinal data on lung function in the first year of life after extracorporeal membrane oxygenation are lacking.Design: Prospective longitudinal cohort study.Setting: Outpatient clinic of a tertiary level pediatric hospital.Patients: The cohort consisted of 64 infants; 33 received extracorporeal membrane oxygenation for meconium aspiration syndrome, 14 for congenital diaphragmatic hernia, four for sepsis, six for persistent pulmonary hypertension of the neonate, and seven for respiratory distress syndrome of infancy. Evaluation was at 6 mos and 12 mos; 39 infants were evaluated at both time points.Interventions: None.Measurements and Main Results: Functional residual capacity and forced expiratory flow at functional residual capacity were measured and expressed as z score. Mean (sem) functional resid-ual capacities in z score were 0.0 (0.2) and 0.2 (0.2) at 6 mos and 12 mos, respectively. Mean (sem) forced expiratory flow was significantly below average (z score = 0) (p < .001) at 6 mos and 12 mos: -1.1 (0.1) and -1.2 (0.1), respectively. At 12 mos, infants with diaphragmatic hernia had a functional residual capacity significantly above normal: mean (sem) z score = 1.2 (0.5).Conclusions: Infants treated with extracorporeal membrane oxygenation have normal lung volumes and stable forced expiratory flows within normal range, although below average, within the first year of life. There is reason to believe, therefore, that extracorporeal membrane oxygenation either ameliorates the harmful effects of mechanical ventilation or somehow preserves lung function in the very ill neonate.
机译：目的：收集体外膜氧合后生命第一年的肺功能纵向数据，并评估肺功能与围产期因素之间的关系。缺乏体外膜氧合后生命第一年的肺功能纵向数据。设计：前瞻性纵向队列研究背景：患者：三级儿科医院的门诊患者。 33例因胎粪吸入综合征而接受了体外膜氧合作用，14例因先天性diaphragm肌疝，4例因败血症，6例因新生儿持续性肺动脉高压，7例因婴儿的呼吸窘迫综合征而接受了体外膜氧合。评估时间为6个月和12个月;在两个时间点对39例婴儿进行了评估。干预措施：无。测量和主要结果：测量功能残余容量和在功能残余容量下的强制呼气流量，并表示为z评分。 z评分的平均（sem）功能残差能力在6个月和12个月时分别为0.0（0.2）和0.2（0.2）。在6个月和12个月时，平均（sem）强迫呼气流量明显低于平均值（z评分= 0）（p <.001）：分别为-1.1（0.1）和-1.2（0.1）。在12个月大时，diaphragm肌疝婴儿的功能残余能力明显高于正常水平：z均值= 1.2（0.5）。结论：经体外膜氧合治疗的婴儿的肺量正常，并且强迫呼气流量在正常范围内，虽然低于平均水平，但在生命的第一年内。因此，我们有理由相信，体外膜氧合可以减轻机械通气的有害影响，或者以某种方式保留重症新生儿的肺功能。

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