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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Mycophenolate mofetil during pregnancy: some words of caution.
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Mycophenolate mofetil during pregnancy: some words of caution.

机译：孕期霉酚酸酯：有些警告。

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摘要

International transplant registries have accounted for more than 14 000 deliveries in solid organ transplant recipient women up to 2002; thus, the possibility of becoming pregnant has been considered an additional benefit of organ transplantation. Improvement in organ transplantation outcome has been linked with the development of more effective immunosuppressive drugs. Hence, in recent years new pharmacologic agents have been incorporated into the armamentarium for organ transplant recipients and patients with autoimmune diseases. Among the new drugs, mycophenolate mofetil (MMF) has acquired special relevance. In addition, MMF has also been added to the treatment of autoimmune diseases such as lupus, because its use has been found to be more effective than cydophosphamide, the standard treatment modality, in inducing remission of lupus nephritis and has a more favorable safety profile.
机译：截止到2002年，国际器官移植登记处已向实体器官移植受孕妇女提供了14000多个分娩;因此，怀孕的可能性被认为是器官移植的另一个好处。器官移植结果的改善与更有效的免疫抑制药物的开发有关。因此，近年来，针对器官移植接受者和自身免疫性疾病患者的军械库中已经加入了新的药物。在新药中，霉酚酸酯（MMF）具有特殊的意义。此外，MMF还被添加到自身免疫性疾病（如狼疮）的治疗中，因为已发现MMF的使用比环磷酰胺（标准治疗方式）更有效，可减轻狼疮性肾炎，并具有更有利的安全性。

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